Chronic citalopram treatment does not sensitise the adrenal gland to ACTH (1-24) in rats

SA Hesketh, JD Leggett, DS Jessop

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

We have previously reported that rats exposed chronically to citalopram are able to elicit a corticosterone but not adrenocorticotropic hormone (ACTH) response to restraint stress. Thus we proposed the hypothesis that the corticosterone response to restraint in citalopram-treated rats was maintained due to increased adrenal sensitivity to lower ACTH levels. To test this hypothesis, we intravenously injected ACTH (1—24) to rats (dose 3 ng/rat) exposed to citalopram through minipump infusion for 14 days and to control rats (no citalopram). ACTH significantly increased plasma corticosterone levels in both control and citalopram treated rats over a period of 120 min. There was no significant difference in plasma corticosterone between citalopram treated rats and control rats at any time point. Therefore we conclude that, under these experimental conditions, citalopram does not appear to sensitize the rodent adrenal gland to ACTH, and that other mechanisms may be responsible for the ACTH/corticosterone disconnection.
Translated title of the contributionChronic citalopram treatment does not sensitise the adrenal gland to ACTH (1-24) in rats
Original languageEnglish
Pages (from-to)885 - 887
Number of pages3
JournalJournal of Psychopharmacology
Volume21 (8)
DOIs
Publication statusPublished - Nov 2007

Bibliographical note

Publisher: Sage

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