Chronic maladaptive pain in cats: A review of current and future drug treatment options

Derek Adrian; Mark Papich; Ron Baynes; Jo Murrell; B. Duncan X. Lascelles

doi:10.1016/j.tvjl.2017.08.006

Chronic maladaptive pain in cats: A review of current and future drug treatment options

Derek Adrian, Mark Papich, Ron Baynes, Jo Murrell, B. Duncan X. Lascelles

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Abstract

Despite our increasing understanding of the pathophysiology underlying chronic or maladaptive pain, there is a significant gap in our ability to diagnose and treat the condition in domestic cats. Newer techniques being used to identify abnormalities in pain processing in the cat include validated owner questionnaires, measurement of movement and activity, and measurement of sensory thresholds and somatomotor responses. While some data are available evaluating possible therapeutics for the treatment of chronic pain in the cat, most data are limited to normal cats. This review details our current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats.

Original language	English
Pages (from-to)	52-61
Number of pages	10
Journal	Veterinary Journal
Volume	230
Early online date	20 Aug 2017
DOIs	https://doi.org/10.1016/j.tvjl.2017.08.006
Publication status	Published - 10 Dec 2017

Keywords

Maladaptive pain
Cats
Analgesia
Central plasticity
Chronic pain

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This is the author accepted manuscript (AAM). The final published version (version of record) is available online via Elsevier at https://www.sciencedirect.com/science/article/pii/S1090023317301570 . Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 995 KBLicence: CC BY-NC-ND

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title = "Chronic maladaptive pain in cats: A review of current and future drug treatment options",

abstract = "Despite our increasing understanding of the pathophysiology underlying chronic or maladaptive pain, there is a significant gap in our ability to diagnose and treat the condition in domestic cats. Newer techniques being used to identify abnormalities in pain processing in the cat include validated owner questionnaires, measurement of movement and activity, and measurement of sensory thresholds and somatomotor responses. While some data are available evaluating possible therapeutics for the treatment of chronic pain in the cat, most data are limited to normal cats. This review details our current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats.",

keywords = "Maladaptive pain, Cats, Analgesia, Central plasticity, Chronic pain",

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T1 - Chronic maladaptive pain in cats

T2 - A review of current and future drug treatment options

AU - Adrian, Derek

AU - Papich, Mark

AU - Baynes, Ron

AU - Murrell, Jo

AU - Lascelles, B. Duncan X.

PY - 2017/12/10

Y1 - 2017/12/10

N2 - Despite our increasing understanding of the pathophysiology underlying chronic or maladaptive pain, there is a significant gap in our ability to diagnose and treat the condition in domestic cats. Newer techniques being used to identify abnormalities in pain processing in the cat include validated owner questionnaires, measurement of movement and activity, and measurement of sensory thresholds and somatomotor responses. While some data are available evaluating possible therapeutics for the treatment of chronic pain in the cat, most data are limited to normal cats. This review details our current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats.

AB - Despite our increasing understanding of the pathophysiology underlying chronic or maladaptive pain, there is a significant gap in our ability to diagnose and treat the condition in domestic cats. Newer techniques being used to identify abnormalities in pain processing in the cat include validated owner questionnaires, measurement of movement and activity, and measurement of sensory thresholds and somatomotor responses. While some data are available evaluating possible therapeutics for the treatment of chronic pain in the cat, most data are limited to normal cats. This review details our current understanding of chronic or maladaptive pain, techniques for the detection and measurement of the condition and the associated central nervous changes, as well as an overview of the data evaluating potential therapeutics in cats.

KW - Maladaptive pain

KW - Cats

KW - Analgesia

KW - Central plasticity

KW - Chronic pain

U2 - 10.1016/j.tvjl.2017.08.006

DO - 10.1016/j.tvjl.2017.08.006

M3 - Article (Academic Journal)

C2 - 28887012

SN - 1090-0233

VL - 230

SP - 52

EP - 61

JO - Veterinary Journal

JF - Veterinary Journal

ER -

Chronic maladaptive pain in cats: A review of current and future drug treatment options

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