Cicada-inspired cell-instructive nanopatterned arrays

Ting Diu, Nilofar Faruqui, Terje Sjöström, Baptiste Lamarre, Howard F Jenkinson, Bo Su, Maxim G Ryadnov

Research output: Contribution to journalArticle (Academic Journal)

106 Citations (Scopus)
343 Downloads (Pure)

Abstract

Biocompatible surfaces hold key to a variety of biomedical problems that are directly related to the competition between host-tissue cell integration and bacterial colonisation. A saving solution to this is seen in the ability of cells to uniquely respond to physical cues on such surfaces thus prompting the search for cell-instructive nanoscale patterns. Here we introduce a generic rationale engineered into biocompatible, titanium, substrates to differentiate cell responses. The rationale is inspired by cicada wing surfaces that display bactericidal nanopillar patterns. The surfaces engineered in this study are titania (TiO2) nanowire arrays that are selectively bactericidal against motile bacteria, while capable of guiding mammalian cell proliferation according to the type of the array. The concept holds promise for clinically relevant materials capable of differential physico-mechanical responses to cellular adhesion.

Original languageEnglish
Article number7122
Number of pages7
JournalScientific Reports
Volume4
DOIs
Publication statusPublished - 20 Nov 2014

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    Diu, T., Faruqui, N., Sjöström, T., Lamarre, B., Jenkinson, H. F., Su, B., & Ryadnov, M. G. (2014). Cicada-inspired cell-instructive nanopatterned arrays. Scientific Reports, 4, [7122]. https://doi.org/10.1038/srep07122