Circadian dynamics in measures of cortical excitation and inhibition balance

Sarah Chellappa, Christelle Meyer, Giulia Gaggioni, Julien Ly, Mario Rosanova, Sarasso Simone, Simon Archer, André Luxen, Derk-Jan Dijk, Marcello Massimini, Pierre Maquet, Christophe Phillips, Rosalyn Moran, Gilles Vandewalle

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Abstract

Several neuropsychiatric and neurological disorders have recently been characterized as dysfunctions arising from a ‘final common pathway’ of imbalanced excitation to inhibition within cortical networks. How the regulation of a cortical E/I ratio is affected by sleep and the circadian rhythm however, remains to be established. Here we addressed this issue through the analyses of TMS-evoked responses recorded over a 29 h sleep deprivation protocol conducted in young and healthy volunteers. Spectral analyses of TMS-evoked responses in frontal cortex revealed non-linear changes in gamma band evoked oscillations, compatible with an influence of circadian timing on inhibitory interneuron activity. In silico inferences of cell-to-cell excitatory and inhibitory connectivity and GABA/Glutamate receptor time constant based on neural mass modeling within the Dynamic causal modeling framework, further suggested excitation/inhibition balance was under a strong circadian influence. These results indicate that circadian changes in EEG spectral properties, in measure of excitatory/inhibitory connectivity and in GABA/glutamate receptor function could support the maintenance of cognitive performance during a normal waking day, but also during overnight wakefulness. More generally, these findings demonstrate a slow daily regulation of cortical excitation/inhibition balance, which depends on circadian-timing and prior sleep-wake history.
Original languageEnglish
Article number33661
Number of pages13
JournalScientific Reports
Volume6
DOIs
Publication statusPublished - 21 Sep 2016

Keywords

  • Circadian mechanisms
  • Circadian regulation

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    Chellappa, S., Meyer, C., Gaggioni, G., Ly, J., Rosanova, M., Simone, S., Archer, S., Luxen, A., Dijk, D-J., Massimini, M., Maquet, P., Phillips, C., Moran, R., & Vandewalle, G. (2016). Circadian dynamics in measures of cortical excitation and inhibition balance. Scientific Reports, 6, [33661]. https://doi.org/10.1038/srep33661