Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

María Carmen Martí Ruiz; Katharine E. Hubbard; Michael J. Gardner; Hyun Ju Jung; Sylvain Aubry; Carlos T. Hotta; Nur Izzati Mohd-Noh; Fiona C. Robertson; Timothy J. Hearn; Yu Chang Tsai; Antony N. Dodd; Matthew Hannah; Isabelle A. Carré; Julia M. Davies; Janet Braam; Alex A.R. Webb

doi:10.1038/s41477-018-0224-8

Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

María Carmen Martí Ruiz, Katharine E. Hubbard, Michael J. Gardner, Hyun Ju Jung, Sylvain Aubry, Carlos T. Hotta, Nur Izzati Mohd-Noh, Fiona C. Robertson, Timothy J. Hearn, Yu Chang Tsai, Antony N. Dodd, Matthew Hannah, Isabelle A. Carré, Julia M. Davies, Janet Braam, Alex A.R. Webb^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca²⁺ ([Ca²⁺]_cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca²⁺]_cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca²⁺]_cyt circadian oscillations can regulate circadian clock function through the Ca²⁺-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).

Original language	English
Pages (from-to)	690-698
Number of pages	9
Journal	Nature Plants
Volume	4
Issue number	9
Early online date	20 Aug 2018
DOIs	https://doi.org/10.1038/s41477-018-0224-8
Publication status	Published - Sept 2018

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Martí Ruiz, M. C., Hubbard, K. E., Gardner, M. J., Jung, H. J., Aubry, S., Hotta, C. T., Mohd-Noh, N. I., Robertson, F. C., Hearn, T. J., Tsai, Y. C., Dodd, A. N., Hannah, M., Carré, I. A., Davies, J. M., Braam, J., & Webb, A. A. R. (2018). Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock. Nature Plants, 4(9), 690-698. https://doi.org/10.1038/s41477-018-0224-8

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title = "Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock",

abstract = "In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).",

author = "{Mart{\'i} Ruiz}, {Mar{\'i}a Carmen} and Hubbard, {Katharine E.} and Gardner, {Michael J.} and Jung, {Hyun Ju} and Sylvain Aubry and Hotta, {Carlos T.} and Mohd-Noh, {Nur Izzati} and Robertson, {Fiona C.} and Hearn, {Timothy J.} and Tsai, {Yu Chang} and Dodd, {Antony N.} and Matthew Hannah and Carr{\'e}, {Isabelle A.} and Davies, {Julia M.} and Janet Braam and Webb, {Alex A.R.}",

year = "2018",

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doi = "10.1038/s41477-018-0224-8",

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Martí Ruiz, MC, Hubbard, KE, Gardner, MJ, Jung, HJ, Aubry, S, Hotta, CT, Mohd-Noh, NI, Robertson, FC, Hearn, TJ, Tsai, YC, Dodd, AN, Hannah, M, Carré, IA, Davies, JM, Braam, J & Webb, AAR 2018, 'Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock', Nature Plants, vol. 4, no. 9, pp. 690-698. https://doi.org/10.1038/s41477-018-0224-8

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T1 - Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

AU - Martí Ruiz, María Carmen

AU - Hubbard, Katharine E.

AU - Gardner, Michael J.

AU - Jung, Hyun Ju

AU - Aubry, Sylvain

AU - Hotta, Carlos T.

AU - Mohd-Noh, Nur Izzati

AU - Robertson, Fiona C.

AU - Hearn, Timothy J.

AU - Tsai, Yu Chang

AU - Dodd, Antony N.

AU - Hannah, Matthew

AU - Carré, Isabelle A.

AU - Davies, Julia M.

AU - Braam, Janet

AU - Webb, Alex A.R.

PY - 2018/9

Y1 - 2018/9

N2 - In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).

AB - In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).

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SN - 2055-026X

VL - 4

SP - 690

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JO - Nature Plants

JF - Nature Plants

IS - 9

ER -

Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

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