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Circadian oscillations of cytosolic free calcium regulate the Arabidopsis circadian clock

Research output: Contribution to journalArticle

  • María Carmen Martí Ruiz
  • Katharine E. Hubbard
  • Michael J. Gardner
  • Hyun Ju Jung
  • Sylvain Aubry
  • Carlos T. Hotta
  • Nur Izzati Mohd-Noh
  • Fiona C. Robertson
  • Timothy J. Hearn
  • Yu Chang Tsai
  • Antony N. Dodd
  • Matthew Hannah
  • Isabelle A. Carré
  • Julia M. Davies
  • Janet Braam
  • Alex A.R. Webb
Original languageEnglish
Pages (from-to)690-698
Number of pages9
JournalNature Plants
Issue number9
Early online date20 Aug 2018
DateAccepted/In press - 17 Jul 2018
DateE-pub ahead of print - 20 Aug 2018
DatePublished (current) - Sep 2018


In the last decade, the view of circadian oscillators has expanded from transcriptional feedback to incorporate post-transcriptional, post-translational, metabolic processes and ionic signalling. In plants and animals, there are circadian oscillations in the concentration of cytosolic free Ca2+ ([Ca2+]cyt), though their purpose has not been fully characterized. We investigated whether circadian oscillations of [Ca2+]cyt regulate the circadian oscillator of Arabidopsis thaliana. We report that in Arabidopsis, [Ca2+]cyt circadian oscillations can regulate circadian clock function through the Ca2+-dependent action of CALMODULIN-LIKE24 (CML24). Genetic analyses demonstrate a linkage between CML24 and the circadian oscillator, through pathways involving the circadian oscillator gene TIMING OF CAB2 EXPRESSION1 (TOC1).

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