Circadian rhythms in skin and other elastic tissues

Michael J. Sherratt*, Louise Hopkinson, Mark Naven, Sarah A. Hibbert, Matiss Ozols, Alexander Eckersley, Victoria L. Newton, Mike Bell, Qing Jun Meng

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

30 Citations (Scopus)

Abstract

Circadian rhythms are daily oscillations that, in mammals, are driven by both a master clock, located in the brain, and peripheral clocks in cells and tissues. Approximately 10% of the transcriptome, including extracellular matrix components, is estimated to be under circadian control. Whilst it has been established that certain collagens and extracellular matrix proteases are diurnally regulated (for example in tendon, cartilage and intervertebral disc) the role played by circadian rhythms in mediating elastic fiber homeostasis is poorly understood. Skin, arteries and lungs are dynamic, resilient, elastic fiber-rich organs and tissues. In skin, circadian rhythms influence cell migration and proliferation, wound healing and susceptibility of the tissues to damage (from protease activity, oxidative stress and ultraviolet radiation). In the cardiovascular system, blood pressure and heart rate also follow age-dependent circadian rhythms whilst the lungs exhibit diurnal variations in immune response. In order to better understand these processes it will be necessary to characterise diurnal changes in extracellular matrix biology. In particular, given the sensitivity of peripheral clocks to external factors, the timed delivery of interventions (chronotherapy) has the potential to significantly improve the efficacy of treatments designed to repair and regenerate damaged cutaneous, vascular and pulmonary tissues.

Original languageEnglish
Pages (from-to)97-110
Number of pages14
JournalMatrix Biology
Volume84
DOIs
Publication statusPublished - Nov 2019

Bibliographical note

Funding Information:
This work was supported by a programme grant from Walgreens Boots Alliance (Sherratt and Meng) and an Arthritis Research UK Senior Research Fellowship Award ( 20875 , to Meng) and a MRC project grant ( MR/P010709/1 to Meng).

Publisher Copyright:
© 2019 International Society of Matrix Biology

Keywords

  • Artery
  • Circadian rhythm
  • Elastic fiber
  • Elastin
  • Extracellular matrix
  • Lung
  • Skin

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