Circadian VIPergic Neurons of the Suprachiasmatic Nuclei Sculpt the Sleep-Wake Cycle

Ben Collins*, Sara Pierre-Ferrer , Christine Muheim, David Lukacsovich, Yuchen Cai, Andrea Spinnler, Carolina Gutierrez Herrera, Shao'Ang Wen, Jochen Winterer, Mino D. C. Belle, Hugh D Piggins, Michael Hastings, Andrew S. Loudon, Jun Yan, Csaba Földy, Antoine Adamantidis, Steven A Brown

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

51 Citations (Scopus)
84 Downloads (Pure)

Abstract

Although the mammalian rest-activity cycle is controlled by a "master clock" in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of individual SCN neurons gates individual features of daily activity. Here, we demonstrate that a specific transcriptomically identified population of mouse VIP+ SCN neurons is active at the "wrong" time of day-nighttime-when most SCN neurons are silent. Using chemogenetic and optogenetic strategies, we show that these neurons and their cellular clocks are necessary and sufficient to gate and time nighttime sleep but have no effect upon daytime sleep. We propose that mouse nighttime sleep, analogous to the human siesta, is a "hard-wired" property gated by specific neurons of the master clock to favor subsequent alertness prior to dawn (a circadian "wake maintenance zone"). Thus, the SCN is not simply a 24-h metronome: specific populations sculpt critical features of the sleep-wake cycle.
Original languageEnglish
Pages (from-to)486–499
Number of pages20
JournalNeuron
Volume108
DOIs
Publication statusPublished - 10 Sept 2020

Keywords

  • alertness
  • wake maintenance
  • circadian
  • napping
  • optogenetics
  • siesta
  • sleep
  • vasoactive intestinal polypeptide

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