Circulating insulin-like growth factor-binding protein 3 levels, independent of insulin-like growth factor 1, associate with truncal fat and systolic blood pressure in South Asian and white European preschool children

Leena Patel, Andrew Whatmore, Jill Davies, Narinder Bansal, Avni Vyas, Isla Gemmell, John Oldroyd, J Kennedy Cruickshank, Peter Clayton

Research output: Contribution to journalArticle (Academic Journal)

5 Citations (Scopus)

Abstract

AIMS: To study the effect of the insulin-like growth factor (IGF) system on growth, adiposity and systolic blood pressure (SBP) in early life in British-born South Asian (SA) and White European (WE) children.

METHODS: The effect of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) over the first 4 years in 204 healthy SA and WE children was investigated by mixed linear regression modelling. This enabled inclusion of all follow-up observations and adjustment for repeated measures.

RESULTS: At birth, SA babies were shorter and lighter than WE babies. Over 4 years, SA ethnicity was associated with lower height, weight and body mass index (BMI) standard deviation score (SDS), higher subscapular/triceps skinfold thickness (Ss/Tr SFT) and lower SBP (all p < 0.01). IGF-1 was associated with greater height (p = 0.03), weight (p < 0.001) and BMI SDS (p < 0.001), and IGFBP-3 with greater weight SDS (p < 0.001), BMI SDS (p = 0.001), Ss/Tr SFT (p = 0.003) and SBP (p = 0.023).

CONCLUSIONS: Over this first 4-year period of life, SA ethnicity was associated with being shorter, lighter, having more superficial truncal adiposity and lower SBP. IGFBP-3 (and not IGF-1) was independently associated with both superficial truncal adiposity and SBP, suggesting that IGFBP-3 is a potential metabolic and cardiovascular marker in healthy children in the early years of life.

Original languageEnglish
Pages (from-to)109-17
Number of pages9
JournalHormone Research in Paediatrics
Volume81
Issue number2
DOIs
Publication statusPublished - 2014

Keywords

  • Adiposity
  • Asia
  • Asian Continental Ancestry Group
  • Biomarkers
  • Blood Pressure
  • Body Fat Distribution
  • Body Height
  • Body Weight
  • Child, Preschool
  • Cross-Sectional Studies
  • Europe
  • European Continental Ancestry Group
  • Female
  • Follow-Up Studies
  • Humans
  • Infant
  • Insulin-Like Growth Factor Binding Protein 3
  • Insulin-Like Growth Factor I
  • Linear Models
  • Longitudinal Studies
  • Male
  • Systole
  • Comparative Study
  • Journal Article
  • Observational Study
  • Research Support, Non-U.S. Gov't

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