Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy

F Olajide; R J Howell; J A Wass; J M Holly; H Bohn; J G Grudzinskas; M G Chapman; T Chard

Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy

F Olajide, R J Howell, J A Wass, J M Holly, H Bohn, J G Grudzinskas, M G Chapman, T Chard

Bristol Medical School (THS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

9 Citations (Scopus)

Abstract

First trimester termination of pregnancy was successfully induced in ten patients with RU 38486 followed 2 days later by a prostaglandin (Gemeprost) pessary. Human chorionic gonadotrophin (HCG) values remained unaltered until after the abortion. The levels of placental protein 12 (PP12) showed an immediate and significant fall following RU 38486, then rose to values substantially higher than those at the initial visit after 2 days. These findings show that RU 38486 has a direct inhibitory effect on tissues producing PP12 and confirm the progesterone dependency of this protein.

Original language	English
Pages (from-to)	337-40
Number of pages	4
Journal	Human Reproduction
Volume	4
Issue number	3
Publication status	Published - 1989

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@article{17f2f98dd2e243d3a57647f956a00e39,

title = "Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy",

abstract = "First trimester termination of pregnancy was successfully induced in ten patients with RU 38486 followed 2 days later by a prostaglandin (Gemeprost) pessary. Human chorionic gonadotrophin (HCG) values remained unaltered until after the abortion. The levels of placental protein 12 (PP12) showed an immediate and significant fall following RU 38486, then rose to values substantially higher than those at the initial visit after 2 days. These findings show that RU 38486 has a direct inhibitory effect on tissues producing PP12 and confirm the progesterone dependency of this protein.",

author = "F Olajide and Howell, {R J} and Wass, {J A} and Holly, {J M} and H Bohn and Grudzinskas, {J G} and Chapman, {M G} and T Chard",

year = "1989",

language = "English",

volume = "4",

pages = "337--40",

journal = "Human Reproduction",

issn = "0268-1161",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy

AU - Olajide, F

AU - Howell, R J

AU - Wass, J A

AU - Holly, J M

AU - Bohn, H

AU - Grudzinskas, J G

AU - Chapman, M G

AU - Chard, T

PY - 1989

Y1 - 1989

N2 - First trimester termination of pregnancy was successfully induced in ten patients with RU 38486 followed 2 days later by a prostaglandin (Gemeprost) pessary. Human chorionic gonadotrophin (HCG) values remained unaltered until after the abortion. The levels of placental protein 12 (PP12) showed an immediate and significant fall following RU 38486, then rose to values substantially higher than those at the initial visit after 2 days. These findings show that RU 38486 has a direct inhibitory effect on tissues producing PP12 and confirm the progesterone dependency of this protein.

AB - First trimester termination of pregnancy was successfully induced in ten patients with RU 38486 followed 2 days later by a prostaglandin (Gemeprost) pessary. Human chorionic gonadotrophin (HCG) values remained unaltered until after the abortion. The levels of placental protein 12 (PP12) showed an immediate and significant fall following RU 38486, then rose to values substantially higher than those at the initial visit after 2 days. These findings show that RU 38486 has a direct inhibitory effect on tissues producing PP12 and confirm the progesterone dependency of this protein.

M3 - Article (Academic Journal)

C2 - 2715311

SN - 0268-1161

VL - 4

SP - 337

EP - 340

JO - Human Reproduction

JF - Human Reproduction

IS - 3

ER -

Circulating levels of placental protein 12 and chorionic gonadotrophin following RU 38486 and gemeprost for termination of first trimester pregnancy

Abstract

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