Circulating Serum Magnesium and Risk of Venous Thromboembolism in Men: A Long-term Prospective Cohort Study

Setor K Kunutsor*, Jari Laukkanen

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

Abstract

Background and Objective: Serum magnesium, an essential trace element involved in processes that regulate cardiovascular function, has been linked to the risk of atherosclerotic cardiovascular disease. However, the potential association between serum magnesium and venous thromboembolism (VTE) has not been previously investigated. We aimed to assess the prospective association of serum magnesium with the risk of VTE.

Methods: Serum magnesium was measured using atomic absorption spectrometry in 2,361 men aged 42-61 years without a history of VTE at baseline in the Kuopio Ischemic Heart Disease prospective cohort. Cox-regression models were used to calculate hazard ratios (HR) with 95% confidence interval (CI) for VTE.

Results: A total of 159 incident VTE events were recorded during a median follow-up of 27.1 years. The risk of VTE per 1 standard deviation increase in serum magnesium in age-adjusted analysis was (HR 1.30; 95% CI 0.46-3.69). The association remained consistent in analyses adjusted for systolic blood pressure, body mass index, total cholesterol, triglycerides, smoking status, histories of type 2 diabetes and coronary heart disease, medication for dyslipidemia, alcohol consumption, physical activity, socioeconomic status, serum active calcium, high sensitivity C-reactive protein and history of cancer (HR 1.38; 95% CI 0.48–3.96). Comparing the extreme tertiles of serum magnesium, the corresponding adjusted HRs were 1.17 (95% CI: 0.81-1.70) and 1.17 (95% CI: 0.81-1.70).

Conclusion: In a middle-aged Caucasian male population, serum circulating magnesium was not associated with future risk of VTE. Further studies in women, other age-groups and other populations are required to generalize these findings.
Original languageEnglish
JournalPulse
Publication statusAccepted/In press - 18 Feb 2021

Keywords

  • serum magnesium
  • venous thromboembolism
  • cohort study

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