Clinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach

P Lagergren, P Fayers, T Conroy, HJ Stein, O Sezer, R Hardwick, E Hammerlid, A Bottomley, E Van Cutsem, JM Blazeby, Groups on behalf of the European Organisation for Research Treatment of Cancer Gastrointestinal and Quality of Life

Research output: Contribution to journalArticle (Academic Journal)peer-review

91 Citations (Scopus)

Abstract

Aim To combine and test the EORTC questionnaires for assessing quality of life (HRQL) for oesophageal (QLQ-OES18) and stomach cancer (QLQ-STO22), into a single questionnaire for tumours of the oesophagus, oesophago-gastric junction or stomach. Methods The QLQ-OES18, QLQ-STO22 and seven modified items were administered to 300 patients with oesophageal (n = 148), junctional (n = 66), or gastric cancer (n = 86). Semi-structured interviews assessed item and scale preference and multi-trait scaling analyses confirmed the scale structure of the new module (QLQ-OG25). This was further tested for validity. Results The QLQ-OG25 has six scales, dysphagia, eating restrictions, reflux, odynophagia, pain and anxiety. Scales have good reliability ([alpha] range 0.67-0.87) and they distinguish between tumour sites and disease stage. Scales do not correlate highly with scores from the core questionnaire, thus indicating that the module was addressing separate HRQL aspects. Conclusion The QLQ-OG25 is recommended to supplement the EORTC QLQ-C30 when assessing HRQL in patients with oesophageal, junctional or gastric cancer.
Translated title of the contributionClinical and psychometric validation of a questionnaire module, the EORTC QLQ-OG25, to assess health-related quality of life in patients with cancer of the oesophagus, the oesophago-gastric junction and the stomach
Original languageEnglish
Pages (from-to)2066 - 2073
Number of pages8
JournalEuropean Journal of Cancer
Volume43 (14)
DOIs
Publication statusPublished - Sep 2007

Bibliographical note

Publisher: Elsevier
Other identifier: PMID: 17702567

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