Clinical and sociodemographic comparison of people at high-risk for psychosis and with first-episode psychosis

J Zimbrón, S Ruiz de Azúa, G M Khandaker, P K Gandamaneni, C M Crane, A González-Pinto, J Stochl, P B Jones, J Pérez

Research output: Contribution to journalArticle (Academic Journal)peer-review

21 Citations (Scopus)


OBJECTIVE: To compare clinical and sociodemographic characteristics previously associated with psychosis, between individuals at high-risk for psychosis (HR) and patients experiencing a first episode psychosis (FEP), to achieve a better understanding of factors associated with psychosis.

METHOD: Cross-sectional comparison of 30 individuals at HR with 30 age-gender matched FEP, presenting to an early intervention service for psychosis. Participants were followed-up for 2 years to establish the proportion of HR who made the transition into FEP.

RESULTS: Both groups showed similar socio-clinical characteristics, including immigration status, employment history, marital status, family history of psychotic illness, self-harm and alcohol and drug use. The HR group had a lower level of education, higher burden of trauma, earlier onset of psychiatric symptoms and a longer delay in accessing specialised services. A younger onset of symptoms was associated with a longer delay in accessing services in both groups. After a 2 year follow-up, only three (10%) of the HR group made a transition into FEP.

CONCLUSION: The similarities observed between individuals at HR and those with FEP suggest that known variables associated with psychosis may be equally prevalent in people at HR who do not develop a psychotic disorder.

Original languageEnglish
Pages (from-to)210-6
Number of pages7
JournalActa Psychiatrica Scandinavica
Issue number3
Publication statusPublished - Mar 2013


  • Adolescent
  • Adult
  • Cross-Sectional Studies
  • Educational Status
  • Employment/statistics & numerical data
  • Ethnic Groups/psychology
  • Female
  • Follow-Up Studies
  • Humans
  • Male
  • Marital Status/statistics & numerical data
  • Prevalence
  • Psychiatric Status Rating Scales/statistics & numerical data
  • Psychotic Disorders/epidemiology
  • Risk Factors
  • Socioeconomic Factors
  • United Kingdom/epidemiology
  • Young Adult


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