Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis

H. P. Heikkila*, A. K. Lappalainen, M. J. Day, C. Clercx, M. M. Rajamaki

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

53 Citations (Scopus)

Abstract

Background

Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).

Objective

To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.

Animals

Twelve WHWTs with IPF and 14 healthy control WHWTs.

Method

Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.

Results

Mean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P

Conclusion and Clinical Importance

IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.

Original languageEnglish
Pages (from-to)433-439
Number of pages7
JournalJournal of Veterinary Internal Medicine
Volume25
Issue number3
DOIs
Publication statusPublished - 2011

Keywords

  • LUNG-DISEASE
  • High-resolution computed tomography
  • Interstitial lung disease
  • Dog
  • USUAL INTERSTITIAL PNEUMONIA
  • DOGS
  • Bronchoalveolar lavage
  • BRONCHOALVEOLAR LAVAGE
  • Arterial blood gases

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