Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis

H. P. Heikkila; A. K. Lappalainen; M. J. Day; C. Clercx; M. M. Rajamaki

doi:10.1111/j.1939-1676.2011.0694.x

Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis

H. P. Heikkila^*, A. K. Lappalainen, M. J. Day, C. Clercx, M. M. Rajamaki

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

65 Citations (Scopus)

Abstract

Background

Idiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).

Objective

To describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.

Animals

Twelve WHWTs with IPF and 14 healthy control WHWTs.

Method

Prospective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.

Results

Mean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P

Conclusion and Clinical Importance

IPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.

Original language	English
Pages (from-to)	433-439
Number of pages	7
Journal	Journal of Veterinary Internal Medicine
Volume	25
Issue number	3
DOIs	https://doi.org/10.1111/j.1939-1676.2011.0694.x
Publication status	Published - 2011

Keywords

LUNG-DISEASE
High-resolution computed tomography
Interstitial lung disease
Dog
USUAL INTERSTITIAL PNEUMONIA
DOGS
Bronchoalveolar lavage
BRONCHOALVEOLAR LAVAGE
Arterial blood gases

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@article{0372ce5dc039414192f767eb4c5facbc,

title = "Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis",

abstract = "BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).ObjectiveTo describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.AnimalsTwelve WHWTs with IPF and 14 healthy control WHWTs.MethodProspective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.ResultsMean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P Conclusion and Clinical ImportanceIPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.",

keywords = "LUNG-DISEASE, High-resolution computed tomography, Interstitial lung disease, Dog, USUAL INTERSTITIAL PNEUMONIA, DOGS, Bronchoalveolar lavage, BRONCHOALVEOLAR LAVAGE, Arterial blood gases",

author = "Heikkila, {H. P.} and Lappalainen, {A. K.} and Day, {M. J.} and C. Clercx and Rajamaki, {M. M.}",

year = "2011",

doi = "10.1111/j.1939-1676.2011.0694.x",

language = "English",

volume = "25",

pages = "433--439",

journal = "Journal of Veterinary Internal Medicine",

issn = "0891-6640",

publisher = "Wiley",

number = "3",

}

Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis. / Heikkila, H. P.; Lappalainen, A. K.; Day, M. J. et al.

In: Journal of Veterinary Internal Medicine, Vol. 25, No. 3, 2011, p. 433-439.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis

AU - Heikkila, H. P.

AU - Lappalainen, A. K.

AU - Day, M. J.

AU - Clercx, C.

AU - Rajamaki, M. M.

PY - 2011

Y1 - 2011

N2 - BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).ObjectiveTo describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.AnimalsTwelve WHWTs with IPF and 14 healthy control WHWTs.MethodProspective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.ResultsMean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P Conclusion and Clinical ImportanceIPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.

AB - BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic, interstitial lung disease primarily affecting West Highland White Terriers (WHWTs).ObjectiveTo describe the clinicopathological and diagnostic imaging features in WHWTs with IPF.AnimalsTwelve WHWTs with IPF and 14 healthy control WHWTs.MethodProspective study. Clinical signs and findings of physical examination, blood and arterial blood gas analyses, radiography, high-resolution computed tomography (HRCT), bronchoscopy and bronchoalveolar lavage (BAL) of IPF dogs were obtained and compared with controls. Histopathologic changes in IPF dogs were evaluated.ResultsMean partial pressure of oxygen was significantly lower in IPF (mean +/- SD, 65.5 +/- 15.4 mmHg) than in controls (99.1 +/- 7.8 mmHg, P Conclusion and Clinical ImportanceIPF causes substantial hypoxemia. In HRCT, GGO is a consistent finding. IPF dogs have concurrent airway changes and an increase in BALF TCC.

KW - LUNG-DISEASE

KW - High-resolution computed tomography

KW - Interstitial lung disease

KW - Dog

KW - USUAL INTERSTITIAL PNEUMONIA

KW - DOGS

KW - Bronchoalveolar lavage

KW - BRONCHOALVEOLAR LAVAGE

KW - Arterial blood gases

U2 - 10.1111/j.1939-1676.2011.0694.x

DO - 10.1111/j.1939-1676.2011.0694.x

M3 - Article (Academic Journal)

C2 - 21366693

VL - 25

SP - 433

EP - 439

JO - Journal of Veterinary Internal Medicine

JF - Journal of Veterinary Internal Medicine

SN - 0891-6640

IS - 3

ER -

Clinical, Bronchoscopic, Histopathologic, Diagnostic Imaging, and Arterial Oxygenation Findings in West Highland White Terriers with Idiopathic Pulmonary Fibrosis

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Keywords

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