Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis

G M Murray; N Griffith; P Sinnappurajar; D A Al Julandani; S L N Clarke; D P Hawley; Jessy Choi; C M Guly; Athimalaipet V Ramanan

doi:10.1080/09273948.2023.2172591

Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis

G M Murray
, N Griffith
, P Sinnappurajar
, D A Al Julandani
, S L N Clarke
, D P Hawley
, Jessy Choi
, C M Guly
, Athimalaipet V Ramanan^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

14 Citations (Scopus)

Abstract

BACKGROUND: Adalimumab has demonstrated efficacy in non-infectious uveitis. With the introduction of biosimilar agents such as Amgevita, we aimed to quantify efficacy and tolerability compared to Humira in a multi-centre UK cohort.

METHODS: Patients identified from tertiary uveitis clinics in 3 centres, after institution-mandated switching was implemented.

RESULTS: Data collected for 102 patients, aged 2-75 years, with 185 active eyes. Following switch, rates of uveitis flare were not significantly different (13 events before, 21 after, p = .132). Rates of elevated intraocular pressure were decreased (32 before, 25 afterwards, p = .006) and dosing of oral and intra-ocular steroids was stable. Twenty-four patients (24%) requested to return to Humira, commonly due to pain from injection or technical difficulty with the device.

CONCLUSION: Amgevita is safe and effective for inflammatory uveitis with non-inferiority to Humira. Significant numbers of patients requested to switch back due to side effects including injection site reactions.

Original language	English
Pages (from-to)	442-446
Number of pages	5
Journal	Ocular Immunology and Inflammation
Volume	32
Issue number	4
Early online date	21 Feb 2024
DOIs	https://doi.org/10.1080/09273948.2023.2172591
Publication status	Published - 20 Apr 2024

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.

Keywords

Humans
Adalimumab/therapeutic use
Uveitis/drug therapy
Middle Aged
Female
Male
Adult
Biosimilar Pharmaceuticals/therapeutic use
Adolescent
Aged
Child
Child, Preschool
Young Adult
Treatment Outcome
Retrospective Studies
Anti-Inflammatory Agents/therapeutic use
Drug Substitution

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title = "Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis",

abstract = "BACKGROUND: Adalimumab has demonstrated efficacy in non-infectious uveitis. With the introduction of biosimilar agents such as Amgevita, we aimed to quantify efficacy and tolerability compared to Humira in a multi-centre UK cohort.METHODS: Patients identified from tertiary uveitis clinics in 3 centres, after institution-mandated switching was implemented.RESULTS: Data collected for 102 patients, aged 2-75 years, with 185 active eyes. Following switch, rates of uveitis flare were not significantly different (13 events before, 21 after, p = .132). Rates of elevated intraocular pressure were decreased (32 before, 25 afterwards, p = .006) and dosing of oral and intra-ocular steroids was stable. Twenty-four patients (24\%) requested to return to Humira, commonly due to pain from injection or technical difficulty with the device.CONCLUSION: Amgevita is safe and effective for inflammatory uveitis with non-inferiority to Humira. Significant numbers of patients requested to switch back due to side effects including injection site reactions.",

keywords = "Humans, Adalimumab/therapeutic use, Uveitis/drug therapy, Middle Aged, Female, Male, Adult, Biosimilar Pharmaceuticals/therapeutic use, Adolescent, Aged, Child, Child, Preschool, Young Adult, Treatment Outcome, Retrospective Studies, Anti-Inflammatory Agents/therapeutic use, Drug Substitution",

author = "Murray, \{G M\} and N Griffith and P Sinnappurajar and \{Al Julandani\}, \{D A\} and Clarke, \{S L N\} and Hawley, \{D P\} and Jessy Choi and Guly, \{C M\} and Ramanan, \{Athimalaipet V\}",

note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

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doi = "10.1080/09273948.2023.2172591",

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pages = "442--446",

journal = "Ocular Immunology and Inflammation",

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T1 - Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis

AU - Murray, G M

AU - Griffith, N

AU - Sinnappurajar, P

AU - Al Julandani, D A

AU - Clarke, S L N

AU - Hawley, D P

AU - Choi, Jessy

AU - Guly, C M

AU - Ramanan, Athimalaipet V

PY - 2024/4/20

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N2 - BACKGROUND: Adalimumab has demonstrated efficacy in non-infectious uveitis. With the introduction of biosimilar agents such as Amgevita, we aimed to quantify efficacy and tolerability compared to Humira in a multi-centre UK cohort.METHODS: Patients identified from tertiary uveitis clinics in 3 centres, after institution-mandated switching was implemented.RESULTS: Data collected for 102 patients, aged 2-75 years, with 185 active eyes. Following switch, rates of uveitis flare were not significantly different (13 events before, 21 after, p = .132). Rates of elevated intraocular pressure were decreased (32 before, 25 afterwards, p = .006) and dosing of oral and intra-ocular steroids was stable. Twenty-four patients (24%) requested to return to Humira, commonly due to pain from injection or technical difficulty with the device.CONCLUSION: Amgevita is safe and effective for inflammatory uveitis with non-inferiority to Humira. Significant numbers of patients requested to switch back due to side effects including injection site reactions.

AB - BACKGROUND: Adalimumab has demonstrated efficacy in non-infectious uveitis. With the introduction of biosimilar agents such as Amgevita, we aimed to quantify efficacy and tolerability compared to Humira in a multi-centre UK cohort.METHODS: Patients identified from tertiary uveitis clinics in 3 centres, after institution-mandated switching was implemented.RESULTS: Data collected for 102 patients, aged 2-75 years, with 185 active eyes. Following switch, rates of uveitis flare were not significantly different (13 events before, 21 after, p = .132). Rates of elevated intraocular pressure were decreased (32 before, 25 afterwards, p = .006) and dosing of oral and intra-ocular steroids was stable. Twenty-four patients (24%) requested to return to Humira, commonly due to pain from injection or technical difficulty with the device.CONCLUSION: Amgevita is safe and effective for inflammatory uveitis with non-inferiority to Humira. Significant numbers of patients requested to switch back due to side effects including injection site reactions.

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KW - Biosimilar Pharmaceuticals/therapeutic use

KW - Adolescent

KW - Aged

KW - Child

KW - Child, Preschool

KW - Young Adult

KW - Treatment Outcome

KW - Retrospective Studies

KW - Anti-Inflammatory Agents/therapeutic use

KW - Drug Substitution

U2 - 10.1080/09273948.2023.2172591

DO - 10.1080/09273948.2023.2172591

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JO - Ocular Immunology and Inflammation

JF - Ocular Immunology and Inflammation

IS - 4

ER -

Clinical Efficacy of Biosimilar Switch of Adalimumab for Management of Uveitis

Abstract

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Keywords

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