Clinical Endocrinology—Time for a Reset?

Stafford L. Lightman*

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review


Measurement of blood levels of circulating hormones has always been the cornerstone of the biochemical diagnosis of endocrine diseases, with the objective of detecting hormone excess or insufficiency. Unfortunately, the dynamic nature of hormone secretion means single-point measurements of many hormones often lack diagnostic validity. Endocrinologists have devised complex dynamic tests as indirect assessments of the functioning of the hormone system under investigation. Recent advances in the measurement of dynamic hormone changes across the day now offer an opportunity to reconsider whether there might be better ways both to diagnose and to monitor the therapy of endocrine conditions.

Original languageEnglish
Article numberbvae024
Number of pages4
JournalJournal of the Endocrine Society
Issue number4
Early online date12 Feb 2024
Publication statusPublished - 1 Apr 2024

Bibliographical note

Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.


  • Addison’s
  • Cushing’s
  • glucocorticoids
  • hyperaldosteronism
  • rhythms
  • stress


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