Clinical findings associated with N-terminal pro-B-type natriuretic peptide measurement in dogs and cats attending first opinion veterinary practices

Sarah E O'Shaughnessy, India Crawford, Elena Arsevska, David Singleton, David Hughes, P.J. Noble, Melanie J Hezzell*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

Background: Clinical findings associated with N-terminal pro-B-type natriuretic peptide (NT-proBNP) measurement in dogs and cats in primary practice, and their relevance to published measurement indications, have not been described.
Methods: Using electronic health record data collected by The Small Animal Veterinary Surveillance Network, appointments at which NT-proBNP was measured were identified using keyword-based text filtering. For these appointments, clinical findings were manually identified from each patient’s clinical narrative (CN) and their frequencies described.
Results: CNs of 3510 appointments (357 dogs and 257 cats) from 99practices were evaluated. The most frequently-recorded clinical findings in dogs were: heart murmur (n=147, 41.2% (95% confidence interval (CI)=36.1-46.3%), coughing (n=83, 23.2% (95% CI=18.8-27.6%)) and panting (n=58, 16.2% (95% CI=12.4-20.0%)) and in cats: heart murmur (n=143, 55.6% (95% CI=49.5-61.7%)), suspected thromboembolism (n=88, 34.2% (95% CI=28.4-40.0%)) and weight loss (n=53, 20.6% (95% CI=15.7-25.5%)). Dyspnoea and tachypnoea were infrequently reported in dogs (n=29, 8.1% (95% CI=5.3-10.9%) and n=21, 5.9% (95% CI=3.5-8.3%), respectively) and cats (n=26, 10.1% (95% CI=6.4-13.8) and n=36, 14.0% (95% CI=9.8-18.2), respectively).
Conclusion: clinical findings referable to cardiac disease were recorded contemporaneously with NT-proBNP measurement and suggested both published and other indications (coughing (in dogs and cats), and serial measurements and thromboembolism (in cats)) for testing.
Original languageEnglish
Article numbere945
Number of pages11
JournalVeterinary Record
Early online date23 Sept 2021
DOIs
Publication statusPublished - 23 Sept 2021

Bibliographical note

Funding Information:
Dr. Hezzell has previously received research and travel funding from IDEXX Laboratories Inc.

Publisher Copyright:
© 2021 The Authors. Veterinary Record published by John Wiley & Sons Ltd on behalf of British Veterinary Association

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