Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup

Vincent J. Gnanapragasam; S. Hori; T. Johnston; D. Smith; K. Muir; R. Alonzi; M. Winkler; A. Warren; J. Staffurth; V. Khoo; A. Tree; A. Macneill; R. McMenemin; M. Mason; P. Cathcart; N. de Souza; P. Sooriakumaran; R. Weston; J. Wylie; E. Hall; A. Lane; W. Cross; I. Syndikus; A. Koupparis

doi:10.1177/2051415816651362

Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup

Vincent J. Gnanapragasam^*, S. Hori, T. Johnston, D. Smith, K. Muir, R. Alonzi, M. Winkler, A. Warren, J. Staffurth, V. Khoo, A. Tree, A. Macneill, R. McMenemin, M. Mason, P. Cathcart, N. de Souza, P. Sooriakumaran, R. Weston, J. Wylie, E. HallA. Lane, W. Cross, I. Syndikus, A. Koupparis

^*Corresponding author for this work

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Abstract

The management of high-risk prostate cancer has become increasingly sophisticated, with refinements in radical therapy and the inclusion of adjuvant local and systemic therapies. Despite this, high-risk prostate cancer continues to have significant treatment failure rates, with progression to metastasis, castrate resistance and ultimately disease-specific death. In an effort to discuss the challenges in this field, the UK National Clinical Research Institute’s Prostate Cancer Clinical Studies localised subgroup convened a multidisciplinary national meeting in the autumn of 2014. The remit of the meeting was to debate and reach a consensus on the key clinical and research challenges in high-risk prostate cancer and to identify themes that the UK would be best placed to pursue to help improve outcomes. This report presents the outcome of those discussions and the key recommendations for future research in this highly heterogeneous disease entity.

Original language	English
Pages (from-to)	369-379
Number of pages	11
Journal	Journal of Clinical Urology
Volume	9
Issue number	6
Early online date	2 Sept 2016
DOIs	https://doi.org/10.1177/2051415816651362
Publication status	Published - 1 Nov 2016

Structured keywords

BTC (Bristol Trials Centre)
Centre for Surgical Research

Keywords

Prostate cancer
high risk
consensus meeting
research priorities
clinical priorities
multidisciplinary panel

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/2051415816651362

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Gnanapragasam, V. J., Hori, S., Johnston, T., Smith, D., Muir, K., Alonzi, R., Winkler, M., Warren, A., Staffurth, J., Khoo, V., Tree, A., Macneill, A., McMenemin, R., Mason, M., Cathcart, P., de Souza, N., Sooriakumaran, P., Weston, R., Wylie, J., ... Koupparis, A. (2016). Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup. Journal of Clinical Urology, 9(6), 369-379. https://doi.org/10.1177/2051415816651362

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abstract = "The management of high-risk prostate cancer has become increasingly sophisticated, with refinements in radical therapy and the inclusion of adjuvant local and systemic therapies. Despite this, high-risk prostate cancer continues to have significant treatment failure rates, with progression to metastasis, castrate resistance and ultimately disease-specific death. In an effort to discuss the challenges in this field, the UK National Clinical Research Institute{\textquoteright}s Prostate Cancer Clinical Studies localised subgroup convened a multidisciplinary national meeting in the autumn of 2014. The remit of the meeting was to debate and reach a consensus on the key clinical and research challenges in high-risk prostate cancer and to identify themes that the UK would be best placed to pursue to help improve outcomes. This report presents the outcome of those discussions and the key recommendations for future research in this highly heterogeneous disease entity.",

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author = "Gnanapragasam, {Vincent J.} and S. Hori and T. Johnston and D. Smith and K. Muir and R. Alonzi and M. Winkler and A. Warren and J. Staffurth and V. Khoo and A. Tree and A. Macneill and R. McMenemin and M. Mason and P. Cathcart and {de Souza}, N. and P. Sooriakumaran and R. Weston and J. Wylie and E. Hall and A. Lane and W. Cross and I. Syndikus and A. Koupparis",

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Gnanapragasam, VJ, Hori, S, Johnston, T, Smith, D, Muir, K, Alonzi, R, Winkler, M, Warren, A, Staffurth, J, Khoo, V, Tree, A, Macneill, A, McMenemin, R, Mason, M, Cathcart, P, de Souza, N, Sooriakumaran, P, Weston, R, Wylie, J, Hall, E, Lane, A, Cross, W, Syndikus, I & Koupparis, A 2016, 'Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup', Journal of Clinical Urology, vol. 9, no. 6, pp. 369-379. https://doi.org/10.1177/2051415816651362

Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup. / Gnanapragasam, Vincent J.; Hori, S.; Johnston, T. et al.
In: Journal of Clinical Urology, Vol. 9, No. 6, 01.11.2016, p. 369-379.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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AU - Smith, D.

AU - Muir, K.

AU - Alonzi, R.

AU - Winkler, M.

AU - Warren, A.

AU - Staffurth, J.

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AU - Tree, A.

AU - Macneill, A.

AU - McMenemin, R.

AU - Mason, M.

AU - Cathcart, P.

AU - de Souza, N.

AU - Sooriakumaran, P.

AU - Weston, R.

AU - Wylie, J.

AU - Hall, E.

AU - Lane, A.

AU - Cross, W.

AU - Syndikus, I.

AU - Koupparis, A.

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AB - The management of high-risk prostate cancer has become increasingly sophisticated, with refinements in radical therapy and the inclusion of adjuvant local and systemic therapies. Despite this, high-risk prostate cancer continues to have significant treatment failure rates, with progression to metastasis, castrate resistance and ultimately disease-specific death. In an effort to discuss the challenges in this field, the UK National Clinical Research Institute’s Prostate Cancer Clinical Studies localised subgroup convened a multidisciplinary national meeting in the autumn of 2014. The remit of the meeting was to debate and reach a consensus on the key clinical and research challenges in high-risk prostate cancer and to identify themes that the UK would be best placed to pursue to help improve outcomes. This report presents the outcome of those discussions and the key recommendations for future research in this highly heterogeneous disease entity.

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KW - high risk

KW - consensus meeting

KW - research priorities

KW - clinical priorities

KW - multidisciplinary panel

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DO - 10.1177/2051415816651362

M3 - Article (Academic Journal)

AN - SCOPUS:84994210623

SN - 2051-4158

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SP - 369

EP - 379

JO - Journal of Clinical Urology

JF - Journal of Clinical Urology

IS - 6

ER -

Gnanapragasam VJ, Hori S, Johnston T, Smith D, Muir K, Alonzi R et al. Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup. Journal of Clinical Urology. 2016 Nov 1;9(6):369-379. Epub 2016 Sept 2. doi: 10.1177/2051415816651362

Clinical management and research priorities for high-risk prostate cancer in the UK: meeting report of a multidisciplinary panel in conjunction with the NCRI Prostate Cancer Clinical Studies Localised Subgroup

Abstract

Structured keywords

Keywords

UN SDGs

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