Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease

Sadaquate Khan; Shazia Javed; Lucy Mooney; Paul White; Puneet Plaha; Alan Whone; Steven S Gill

doi:10.3109/02688697.2012.659297

Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease

Sadaquate Khan, Shazia Javed, Lucy Mooney, Paul White, Puneet Plaha, Alan Whone, Steven S Gill

Research output: Contribution to journal › Article (Academic Journal) › peer-review

32 Citations (Scopus)

Abstract

INTRODUCTION: The Pedunculopontine nucleus is a novel target for deep brain stimulation and this may improve postural instability and gait dysfunction in Parkinson's disease. If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk.

METHODS: 5 Parkinson's disease patients with bilateral caudal Zona Incerta region and Pedunculopontine nucleus electrodes were assessed using the motor component of the Unified Parkinson's Disease Rating Scale. Patients were assessed in the on-medication state to determine the optimal combination of stimulation setting for axial symptom control.

RESULTS: The on-medication composite axial-subscore only showed a statistically significant improvement when bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation was used.

CONCLUSIONS: In the on-medication state bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation is required in order to produce a significant change in the motor Unified Parkinson's Disease Rating Scale axial-subscore from baseline.

Original language	English
Pages (from-to)	722-5
Number of pages	4
Journal	British Journal of Neurosurgery
Volume	26
Issue number	5
DOIs	https://doi.org/10.3109/02688697.2012.659297
Publication status	Published - Oct 2012

Keywords

Deep Brain Stimulation
Humans
Magnetic Resonance Imaging
Male
Middle Aged
Parkinson Disease
Pedunculopontine Tegmental Nucleus
Postoperative Care
Psychomotor Disorders
Stereotaxic Techniques
Subthalamus
Treatment Outcome

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title = "Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease",

abstract = "INTRODUCTION: The Pedunculopontine nucleus is a novel target for deep brain stimulation and this may improve postural instability and gait dysfunction in Parkinson's disease. If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk.METHODS: 5 Parkinson's disease patients with bilateral caudal Zona Incerta region and Pedunculopontine nucleus electrodes were assessed using the motor component of the Unified Parkinson's Disease Rating Scale. Patients were assessed in the on-medication state to determine the optimal combination of stimulation setting for axial symptom control.RESULTS: The on-medication composite axial-subscore only showed a statistically significant improvement when bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation was used.CONCLUSIONS: In the on-medication state bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation is required in order to produce a significant change in the motor Unified Parkinson's Disease Rating Scale axial-subscore from baseline.",

keywords = "Deep Brain Stimulation, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Pedunculopontine Tegmental Nucleus, Postoperative Care, Psychomotor Disorders, Stereotaxic Techniques, Subthalamus, Treatment Outcome",

author = "Sadaquate Khan and Shazia Javed and Lucy Mooney and Paul White and Puneet Plaha and Alan Whone and Gill, {Steven S}",

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Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease. / Khan, Sadaquate; Javed, Shazia; Mooney, Lucy et al.
In: British Journal of Neurosurgery, Vol. 26, No. 5, 10.2012, p. 722-5.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease

AU - Khan, Sadaquate

AU - Javed, Shazia

AU - Mooney, Lucy

AU - White, Paul

AU - Plaha, Puneet

AU - Whone, Alan

AU - Gill, Steven S

PY - 2012/10

Y1 - 2012/10

N2 - INTRODUCTION: The Pedunculopontine nucleus is a novel target for deep brain stimulation and this may improve postural instability and gait dysfunction in Parkinson's disease. If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk.METHODS: 5 Parkinson's disease patients with bilateral caudal Zona Incerta region and Pedunculopontine nucleus electrodes were assessed using the motor component of the Unified Parkinson's Disease Rating Scale. Patients were assessed in the on-medication state to determine the optimal combination of stimulation setting for axial symptom control.RESULTS: The on-medication composite axial-subscore only showed a statistically significant improvement when bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation was used.CONCLUSIONS: In the on-medication state bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation is required in order to produce a significant change in the motor Unified Parkinson's Disease Rating Scale axial-subscore from baseline.

AB - INTRODUCTION: The Pedunculopontine nucleus is a novel target for deep brain stimulation and this may improve postural instability and gait dysfunction in Parkinson's disease. If unilateral Pedunculopontine nucleus stimulation is as efficacious as bilateral stimulation this would lead to less surgical risk.METHODS: 5 Parkinson's disease patients with bilateral caudal Zona Incerta region and Pedunculopontine nucleus electrodes were assessed using the motor component of the Unified Parkinson's Disease Rating Scale. Patients were assessed in the on-medication state to determine the optimal combination of stimulation setting for axial symptom control.RESULTS: The on-medication composite axial-subscore only showed a statistically significant improvement when bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation was used.CONCLUSIONS: In the on-medication state bilateral Pedunculopontine nucleus and caudal Zona Incerta region stimulation is required in order to produce a significant change in the motor Unified Parkinson's Disease Rating Scale axial-subscore from baseline.

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KW - Humans

KW - Magnetic Resonance Imaging

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KW - Middle Aged

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KW - Pedunculopontine Tegmental Nucleus

KW - Postoperative Care

KW - Psychomotor Disorders

KW - Stereotaxic Techniques

KW - Subthalamus

KW - Treatment Outcome

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DO - 10.3109/02688697.2012.659297

M3 - Article (Academic Journal)

C2 - 22404735

SN - 0268-8697

VL - 26

SP - 722

EP - 725

JO - British Journal of Neurosurgery

JF - British Journal of Neurosurgery

IS - 5

ER -

Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease

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Keywords

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