TY - JOUR
T1 - Cobalt-Catalyzed Asymmetric Hydroboration/Cyclization of 1,6-Enynes with Pinacolborane
AU - Yu, Songjie
AU - Wu, Caizhi
AU - Ge, Shaozhong
PY - 2017/5/17
Y1 - 2017/5/17
N2 -
We report a cobalt-catalyzed asymmetric hydroboration/cyclization of 1,6-enynes with catalysts generated from Co(acac)
2
and chiral bisphosphine ligands and activated in situ by reaction with pinacolborane (HBpin). A variety of oxygen-, nitrogen-, and carbon-tethered 1,6-enynes underwent this asymmetric transformation, yielding both alkyl- and vinyl-substituted boronate esters containing chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with high to excellent enantioselectivities (86%-99% ee).
AB -
We report a cobalt-catalyzed asymmetric hydroboration/cyclization of 1,6-enynes with catalysts generated from Co(acac)
2
and chiral bisphosphine ligands and activated in situ by reaction with pinacolborane (HBpin). A variety of oxygen-, nitrogen-, and carbon-tethered 1,6-enynes underwent this asymmetric transformation, yielding both alkyl- and vinyl-substituted boronate esters containing chiral tetrahydrofuran, cyclopentane, and pyrrolidine moieties with high to excellent enantioselectivities (86%-99% ee).
UR - http://www.scopus.com/inward/record.url?scp=85019647073&partnerID=8YFLogxK
U2 - 10.1021/jacs.7b01708
DO - 10.1021/jacs.7b01708
M3 - Article (Academic Journal)
C2 - 28449577
AN - SCOPUS:85019647073
SN - 0002-7863
VL - 139
SP - 6526
EP - 6529
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 19
ER -