Cohort Profile: Andhra Pradesh Children and Parents Study (APCAPS)

Sanjay Kinra, Kv Radha Krishna, Hannah Kuper, Kv Rameshwar Sarma, Poornima Prabhakaran, Vipin Gupta, Gagandeep Kaur Walia, Santhi Bhogadi, Bharati Kulkarni, Aniket Kumar, Aastha Aggarwal, Ruby Gupta, Dorairaj Prabhakaran, K Srinath Reddy, George Davey Smith, Yoav Ben-Shlomo, Shah Ebrahim

Research output: Contribution to journalArticle (Academic Journal)peer-review

60 Citations (Scopus)


The Andhra Pradesh Children and Parents Study (APCAPS) was originally established to study the long-term effects of early-life undernutrition on risk of cardiovascular disease. Its aims were subsequently expanded to include trans-generational influences of other environmental and genetic factors on chronic diseases in rural India. It builds on the Hyderabad Nutrition Trial (HNT) conducted in 1987-90 to compare the effects on birthweight of a protein-calorie supplement for pregnant women and children. The index children of HNT and their mothers were retraced and examined in 2003-05, and the children re-examined as young adults aged 18-21 years in 2009-10. The cohort was expanded to include both parents and siblings of the index children in a recently completed follow-up conducted in 2010-12 (N = ∼6225 out of 10 213 participants). Recruitment of the remaining residents of these 29 villages (N = ∼55 000) in Ranga Reddy district of Andhra Pradesh is now under way. Extensive data on socio-demographic, lifestyle, medical, anthropometric, physiological, vascular and body composition measures, DNA, stored plasma, and assays of lipids and inflammatory markers on APCAPS participants are available. Details of how to access these data are available from the corresponding author.
Original languageEnglish
Pages (from-to)1417-1424
Number of pages7
JournalInternational Journal of Epidemiology
Publication statusPublished - 9 Sept 2013


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