Cohort Profile: The Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort

Abigail Fraser, Corrie Macdonald-Wallis, Kate Tilling, Andrew W Boyd, Jean Golding, George Davey Smith, A J W Henderson, John A A Macleod, Lynn Molloy, Andy Ness, Susan Ring, Scott M. Nelson, Debbie A. Lawlor*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

884 Citations (Scopus)

Abstract

The Avon Longitudinal Study of Children and Parents (ALSPAC) was established to understand how genetic and environmental characteristics influence health and development in parents and children. All pregnant women resident in a defined area in the South West of England, with an expected date of delivery between 1st April 1991 and 31st December 1992, were eligible and 13 761 women (contributing 13 867 pregnancies) were recruited. These women have been followed over the last 19-22 years and have completed up to 20 questionnaires, have had detailed data abstracted from their medical records and have information on any cancer diagnoses and deaths through record linkage. A follow-up assessment was completed 17-18 years postnatal at which anthropometry, blood pressure, fat, lean and bone mass and carotid intima media thickness were assessed, and a fasting blood sample taken. The second follow-up clinic, which additionally measures cognitive function, physical capability, physical activity (with accelerometer) and wrist bone architecture, is underway and two further assessments with similar measurements will take place over the next 5 years. There is a detailed biobank that includes DNA, with genome-wide data available on > 10 000, stored serum and plasma taken repeatedly since pregnancy and other samples; a wide range of data on completed biospecimen assays are available. Details of how to access these data are provided in this cohort profile.

Original languageEnglish
Pages (from-to)97-110
Number of pages14
JournalInternational Journal of Epidemiology
Volume42
Issue number1
Early online date16 Apr 2012
DOIs
Publication statusPublished - Feb 2013

Keywords

  • BODY-MASS INDEX
  • MATERNAL ANTENATAL ANXIETY
  • GESTATIONAL WEIGHT-GAIN
  • BLOOD-PRESSURE CHANGE
  • PREGNANT-WOMEN
  • BEHAVIOURAL/EMOTIONAL PROBLEMS
  • MENDELIAN RANDOMIZATION
  • HYPERTENSIVE DISORDERS
  • DEPRESSIVE SYMPTOMS
  • C677T GENOTYPE

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