Collaborative Depression Trial (CADET): multi-centre randomised controlled trial of collaborative care for depression - study protocol

David A. Richards*, Adwoa Hughes-Morley, Rachel A. Hayes, Ricardo Araya, Michael Barkham, John M. Bland, Peter Bower, John Cape, Carolyn A. Chew-Graham, Linda Gask, Simon Gilbody, Colin Green, David Kessler, Glyn Lewis, Karina Lovell, Chris Manning, Stephen Pilling

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

29 Citations (Scopus)

Abstract

Background: Comprising of both organisational and patient level components, collaborative care is a potentially powerful intervention for improving depression treatment in UK primary Care. However, as previous models have been developed and evaluated in the United States, it is necessary to establish the effect of collaborative care in the UK in order to determine whether this innovative treatment model can replicate benefits for patients outside the US. This Phase III trial was preceded by a Phase II patient level RCT, following the MRC Complex Intervention Framework.

Methods/Design: A multi-centre controlled trial with cluster-randomised allocation of GP practices. GP practices will be randomised to usual care control or to "collaborative care" - a combination of case manager coordinated support and brief psychological treatment, enhanced specialist and GP communication. The primary outcome will be symptoms of depression as assessed by the PHQ-9.

Discussion: If collaborative care is demonstrated to be effective we will have evidence to enable the NHS to substantially improve the organisation of depressed patients in primary care, and to assist primary care providers to deliver a model of enhanced depression care which is both effective and acceptable to patients.

Trial Registration Number: ISRCTN32829227

Original languageEnglish
Article number188
Number of pages9
JournalBMC Health Services Research
Volume9
DOIs
Publication statusPublished - 16 Oct 2009

Keywords

  • MANAGEMENT
  • PROGRAMS
  • ANTIDEPRESSANT TREATMENT
  • COMPLEX INTERVENTIONS
  • HEALTH
  • IMPROVEMENT
  • COST-EFFECTIVENESS
  • DISEASE
  • DISORDER
  • METAANALYSIS

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