Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study

Emla Fitzsimons; Vanessa Moulton; David A Hughes; Samuel Neaves; Karen M Ho; Gibran Hemani; Nicholas John  Timpson; University London; Emily Gilbert; Susan M Ring

doi:10.1332/175795921X16223668101602

Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study

Emla Fitzsimons, Vanessa Moulton, David A Hughes, Samuel Neaves, Karen M Ho, Gibran Hemani, Nicholas John Timpson, University London, Emily Gilbert, Susan M Ring

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Abstract

A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father ‘triads’. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.

Key messages
It describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents.

It analyses response rates and predictors of response.

It details the DNA extraction, genotyping and imputation procedures performed on the data.

Original language	English
Pages (from-to)	69–187
Journal	Longitudinal and Life Course Studies
Volume	13
Issue number	1
DOIs	https://doi.org/10.1332/175795921X16223668101602
Publication status	Published - 1 Jul 2021

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This is the accepted author manuscript (AAM). The final published version (version of record) is available online via Bristol University Press at 10.1332/175795921X16223668101602. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 935 KBLicence: CC BY

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Cite this

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title = "Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study",

abstract = "A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father {\textquoteleft}triads{\textquoteright}. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.Key messagesIt describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents.It analyses response rates and predictors of response.It details the DNA extraction, genotyping and imputation procedures performed on the data.",

author = "Emla Fitzsimons and Vanessa Moulton and Hughes, {David A} and Samuel Neaves and Ho, {Karen M} and Gibran Hemani and Timpson, {Nicholas John} and University London and Emily Gilbert and Ring, {Susan M}",

year = "2021",

month = jul,

day = "1",

doi = "10.1332/175795921X16223668101602",

language = "English",

volume = "13",

pages = "69–187",

journal = "Longitudinal and Life Course Studies",

issn = "1757-9597",

publisher = "Society for Longitudinal and Life Course Studies",

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TY - JOUR

T1 - Collection of genetic data at scale for a nationally representative population

T2 - the UK Millennium Cohort Study

AU - Fitzsimons, Emla

AU - Moulton, Vanessa

AU - Hughes, David A

AU - Neaves, Samuel

AU - Ho, Karen M

AU - Hemani, Gibran

AU - Timpson, Nicholas John

AU - London, University

AU - Gilbert, Emily

AU - Ring, Susan M

PY - 2021/7/1

Y1 - 2021/7/1

N2 - A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father ‘triads’. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.Key messagesIt describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents.It analyses response rates and predictors of response.It details the DNA extraction, genotyping and imputation procedures performed on the data.

AB - A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father ‘triads’. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.Key messagesIt describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents.It analyses response rates and predictors of response.It details the DNA extraction, genotyping and imputation procedures performed on the data.

U2 - 10.1332/175795921X16223668101602

DO - 10.1332/175795921X16223668101602

M3 - Article (Academic Journal)

C2 - 35920643

SN - 1757-9597

VL - 13

SP - 69

EP - 187

JO - Longitudinal and Life Course Studies

JF - Longitudinal and Life Course Studies

IS - 1

ER -

Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study

Abstract

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