Collection of genetic data at scale for a nationally representative population: the UK Millennium Cohort Study

Emla Fitzsimons, Nicholas John Timpson, Vanessa Moulton, David A Hughes, Samuel Neaves, Karen M Ho, Gibran Hemani, Lisa Calderwood, Emily Gilbert, Susan M Ring

Research output: Contribution to journalArticle (Academic Journal)peer-review

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Abstract

A DNA bank has been created from the Millennium Cohort Study (MCS) saliva samples. A total of 23,336 samples are available, from 9,259 cohort members (4,630 males and 4,629 females), 8,898 mothers and 5,179 fathers. There are 4,533 mother, child, father ‘triads’. This paper describes the collection of the saliva samples from cohort members and their biological parents in the MCS. It analyses response rates and predictors of response, and details the DNA extraction, genotyping and imputation procedures performed on the data.

Key messages
It describes the collection of saliva samples in the Millennium Cohort Study, from cohort members and their resident biological parents.

It analyses response rates and predictors of response.

It details the DNA extraction, genotyping and imputation procedures performed on the data.
Original languageEnglish
JournalLongitudinal and Life Course Studies
DOIs
Publication statusPublished - 12 Jul 2021

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