A recent paper in this journal uses molecular dynamics methods to study hydrolysis of guanosine triphosphate (GTP). The author reports that cleavage of the molecule occurs in less than 5 ps, and leads to a number of fragments including a free oxygen atom and a reduced magnesium ion. This conclusion is not in agreement with the known biochemistry and chemical reactivity of GTP or with previous computational studies of its hydrolysis reaction.
|Pages (from-to)||5366-7; discussion 5368-9|
|Journal||Physical Chemistry Chemical Physics|
|Publication status||Published - 7 Dec 2006|
- Chelating Agents
- Guanosine Monophosphate
- Guanosine Triphosphate