Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Cornelius A. Rietveld; Tõnu Esko; Gail Davies; Tune H. Pers; Patrick Turley; Beben Benyamin; Christopher F. Chabris; Valur Emilsson; Andrew D. Johnson; James J. Lee; Christiaan De Leeuw; Riccardo E. Marioni; Sarah E. Medland; Michael B. Miller; Olga Rostapshova; Sven J. Van Der Lee; Anna A E Vinkhuyzen; Najaf Amin; Dalton Conley; Jaime Derringer; Cornelia M. Van Duijn; Rudolf Fehrmann; Lude Franke; Edward L. Glaeser; Narelle K. Hansell; Caroline Hayward; William G. Iacono; Carla Ibrahim-Verbaas; Vincent Jaddoe; Juha Karjalainen; David Laibson; Paul Lichtenstein; David C. Liewald; Patrik K E Magnusson; Nicholas G. Martin; Matt McGue; George McMahon; Nancy L. Pedersen; Steven Pinker; David J. Porteous; Danielle Posthuma; Fernando Rivadeneira; Blair H. Smithk; John M. Starr; Henning Tiemeier; Nicholas J. Timpsonm; Maciej Trzaskowskin; André G. Uitterlinden; Frank C. Verhulst; Mary E. Ward; Margaret J. Wright; George Davey Smith; Ian J. Deary; Magnus Johannesson; Robert Plomin; Peter M. Visscher; Daniel J. Benjamin; David Cesarini; Philipp D. Koellinger

doi:10.1073/pnas.1404623111

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Cornelius A. Rietveld, Tõnu Esko, Gail Davies, Tune H. Pers, Patrick Turley, Beben Benyamin, Christopher F. Chabris, Valur Emilsson, Andrew D. Johnson, James J. Lee, Christiaan De Leeuw, Riccardo E. Marioni, Sarah E. Medland, Michael B. Miller, Olga Rostapshova, Sven J. Van Der Lee, Anna A E Vinkhuyzen, Najaf Amin, Dalton Conley, Jaime DerringerCornelia M. Van Duijn, Rudolf Fehrmann, Lude Franke, Edward L. Glaeser, Narelle K. Hansell, Caroline Hayward, William G. Iacono, Carla Ibrahim-Verbaas, Vincent Jaddoe, Juha Karjalainen, David Laibson, Paul Lichtenstein, David C. Liewald, Patrik K E Magnusson, Nicholas G. Martin, Matt McGue, George McMahon, Nancy L. Pedersen, Steven Pinker, David J. Porteous, Danielle Posthuma, Fernando Rivadeneira, Blair H. Smithk, John M. Starr, Henning Tiemeier, Nicholas J. Timpsonm, Maciej Trzaskowskin, André G. Uitterlinden, Frank C. Verhulst, Mary E. Ward, Margaret J. Wright, George Davey Smith, Ian J. Deary, Magnus Johannesson, Robert Plomin, Peter M. Visscher, Daniel J. Benjamin, David Cesarini, Philipp D. Koellinger^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

132 Citations (Scopus)

Abstract

We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.

Original language	English
Pages (from-to)	13790-13794
Number of pages	5
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	111
Issue number	38
DOIs	https://doi.org/10.1073/pnas.1404623111
Publication status	Published - 23 Sep 2014

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3 Finished

MRC UoB UNITE Unit - programme 3
Timpson, N. J. & Timpson, N. J.
1/06/13 → 31/03/18
Project: Research
MRC UoB UNITE Unit - Programme 1
Davey Smith, G.
1/06/13 → 31/03/18
Project: Research
EXTENSION OF RD1321 VIA IOP.
Golding, J.
1/02/01 → 1/02/06
Project: Research

Professor George Davey Smith
- KZ.Davey-Smith@bristol.ac.uk
- Bristol Population Health Science Institute
- MRC Integrative Epidemiology Unit
- Elizabeth Blackwell Institute for Health Research
- Cancer
- Bristol Medical School (PHS) - Professor of Clinical Epidemiology
Person: Academic , Member, Group lead

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Rietveld, C. A., Esko, T., Davies, G., Pers, T. H., Turley, P., Benyamin, B., Chabris, C. F., Emilsson, V., Johnson, A. D., Lee, J. J., De Leeuw, C., Marioni, R. E., Medland, S. E., Miller, M. B., Rostapshova, O., Van Der Lee, S. J., Vinkhuyzen, A. A. E., Amin, N., Conley, D., ... Koellinger, P. D. (2014). Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. Proceedings of the National Academy of Sciences of the United States of America, 111(38), 13790-13794. https://doi.org/10.1073/pnas.1404623111

Rietveld, Cornelius A. ; Esko, Tõnu ; Davies, Gail ; Pers, Tune H. ; Turley, Patrick ; Benyamin, Beben ; Chabris, Christopher F. ; Emilsson, Valur ; Johnson, Andrew D. ; Lee, James J. ; De Leeuw, Christiaan ; Marioni, Riccardo E. ; Medland, Sarah E. ; Miller, Michael B. ; Rostapshova, Olga ; Van Der Lee, Sven J. ; Vinkhuyzen, Anna A E ; Amin, Najaf ; Conley, Dalton ; Derringer, Jaime ; Van Duijn, Cornelia M. ; Fehrmann, Rudolf ; Franke, Lude ; Glaeser, Edward L. ; Hansell, Narelle K. ; Hayward, Caroline ; Iacono, William G. ; Ibrahim-Verbaas, Carla ; Jaddoe, Vincent ; Karjalainen, Juha ; Laibson, David ; Lichtenstein, Paul ; Liewald, David C. ; Magnusson, Patrik K E ; Martin, Nicholas G. ; McGue, Matt ; McMahon, George ; Pedersen, Nancy L. ; Pinker, Steven ; Porteous, David J. ; Posthuma, Danielle ; Rivadeneira, Fernando ; Smithk, Blair H. ; Starr, John M. ; Tiemeier, Henning ; Timpsonm, Nicholas J. ; Trzaskowskin, Maciej ; Uitterlinden, André G. ; Verhulst, Frank C. ; Ward, Mary E. ; Wright, Margaret J. ; Smith, George Davey ; Deary, Ian J. ; Johannesson, Magnus ; Plomin, Robert ; Visscher, Peter M. ; Benjamin, Daniel J. ; Cesarini, David ; Koellinger, Philipp D. / Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. In: Proceedings of the National Academy of Sciences of the United States of America. 2014 ; Vol. 111, No. 38. pp. 13790-13794.

@article{5d8500764fa04657b4be56194f4a8ad3,

title = "Common genetic variants associated with cognitive performance identified using the proxy-phenotype method",

abstract = "We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.",

author = "Rietveld, {Cornelius A.} and T{\~o}nu Esko and Gail Davies and Pers, {Tune H.} and Patrick Turley and Beben Benyamin and Chabris, {Christopher F.} and Valur Emilsson and Johnson, {Andrew D.} and Lee, {James J.} and {De Leeuw}, Christiaan and Marioni, {Riccardo E.} and Medland, {Sarah E.} and Miller, {Michael B.} and Olga Rostapshova and {Van Der Lee}, {Sven J.} and Vinkhuyzen, {Anna A E} and Najaf Amin and Dalton Conley and Jaime Derringer and {Van Duijn}, {Cornelia M.} and Rudolf Fehrmann and Lude Franke and Glaeser, {Edward L.} and Hansell, {Narelle K.} and Caroline Hayward and Iacono, {William G.} and Carla Ibrahim-Verbaas and Vincent Jaddoe and Juha Karjalainen and David Laibson and Paul Lichtenstein and Liewald, {David C.} and Magnusson, {Patrik K E} and Martin, {Nicholas G.} and Matt McGue and George McMahon and Pedersen, {Nancy L.} and Steven Pinker and Porteous, {David J.} and Danielle Posthuma and Fernando Rivadeneira and Smithk, {Blair H.} and Starr, {John M.} and Henning Tiemeier and Timpsonm, {Nicholas J.} and Maciej Trzaskowskin and Uitterlinden, {Andr{\'e} G.} and Verhulst, {Frank C.} and Ward, {Mary E.} and Wright, {Margaret J.} and Smith, {George Davey} and Deary, {Ian J.} and Magnus Johannesson and Robert Plomin and Visscher, {Peter M.} and Benjamin, {Daniel J.} and David Cesarini and Koellinger, {Philipp D.}",

year = "2014",

month = sep,

day = "23",

doi = "10.1073/pnas.1404623111",

language = "English",

volume = "111",

pages = "13790--13794",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "38",

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Rietveld, CA, Esko, T, Davies, G, Pers, TH, Turley, P, Benyamin, B, Chabris, CF, Emilsson, V, Johnson, AD, Lee, JJ, De Leeuw, C, Marioni, RE, Medland, SE, Miller, MB, Rostapshova, O, Van Der Lee, SJ, Vinkhuyzen, AAE, Amin, N, Conley, D, Derringer, J, Van Duijn, CM, Fehrmann, R, Franke, L, Glaeser, EL, Hansell, NK, Hayward, C, Iacono, WG, Ibrahim-Verbaas, C, Jaddoe, V, Karjalainen, J, Laibson, D, Lichtenstein, P, Liewald, DC, Magnusson, PKE, Martin, NG, McGue, M, McMahon, G, Pedersen, NL, Pinker, S, Porteous, DJ, Posthuma, D, Rivadeneira, F, Smithk, BH, Starr, JM, Tiemeier, H, Timpsonm, NJ, Trzaskowskin, M, Uitterlinden, AG, Verhulst, FC, Ward, ME, Wright, MJ, Smith, GD, Deary, IJ, Johannesson, M, Plomin, R, Visscher, PM, Benjamin, DJ, Cesarini, D & Koellinger, PD 2014, 'Common genetic variants associated with cognitive performance identified using the proxy-phenotype method', Proceedings of the National Academy of Sciences of the United States of America, vol. 111, no. 38, pp. 13790-13794. https://doi.org/10.1073/pnas.1404623111

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method. / Rietveld, Cornelius A.; Esko, Tõnu; Davies, Gail; Pers, Tune H.; Turley, Patrick; Benyamin, Beben; Chabris, Christopher F.; Emilsson, Valur; Johnson, Andrew D.; Lee, James J.; De Leeuw, Christiaan; Marioni, Riccardo E.; Medland, Sarah E.; Miller, Michael B.; Rostapshova, Olga; Van Der Lee, Sven J.; Vinkhuyzen, Anna A E; Amin, Najaf; Conley, Dalton; Derringer, Jaime; Van Duijn, Cornelia M.; Fehrmann, Rudolf; Franke, Lude; Glaeser, Edward L.; Hansell, Narelle K.; Hayward, Caroline; Iacono, William G.; Ibrahim-Verbaas, Carla; Jaddoe, Vincent; Karjalainen, Juha; Laibson, David; Lichtenstein, Paul; Liewald, David C.; Magnusson, Patrik K E; Martin, Nicholas G.; McGue, Matt; McMahon, George; Pedersen, Nancy L.; Pinker, Steven; Porteous, David J.; Posthuma, Danielle; Rivadeneira, Fernando; Smithk, Blair H.; Starr, John M.; Tiemeier, Henning; Timpsonm, Nicholas J.; Trzaskowskin, Maciej; Uitterlinden, André G.; Verhulst, Frank C.; Ward, Mary E.; Wright, Margaret J.; Smith, George Davey; Deary, Ian J.; Johannesson, Magnus; Plomin, Robert; Visscher, Peter M.; Benjamin, Daniel J.; Cesarini, David; Koellinger, Philipp D.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, No. 38, 23.09.2014, p. 13790-13794.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

TY - JOUR

T1 - Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

AU - Rietveld, Cornelius A.

AU - Esko, Tõnu

AU - Davies, Gail

AU - Pers, Tune H.

AU - Turley, Patrick

AU - Benyamin, Beben

AU - Chabris, Christopher F.

AU - Emilsson, Valur

AU - Johnson, Andrew D.

AU - Lee, James J.

AU - De Leeuw, Christiaan

AU - Marioni, Riccardo E.

AU - Medland, Sarah E.

AU - Miller, Michael B.

AU - Rostapshova, Olga

AU - Van Der Lee, Sven J.

AU - Vinkhuyzen, Anna A E

AU - Amin, Najaf

AU - Conley, Dalton

AU - Derringer, Jaime

AU - Van Duijn, Cornelia M.

AU - Fehrmann, Rudolf

AU - Franke, Lude

AU - Glaeser, Edward L.

AU - Hansell, Narelle K.

AU - Hayward, Caroline

AU - Iacono, William G.

AU - Ibrahim-Verbaas, Carla

AU - Jaddoe, Vincent

AU - Karjalainen, Juha

AU - Laibson, David

AU - Lichtenstein, Paul

AU - Liewald, David C.

AU - Magnusson, Patrik K E

AU - Martin, Nicholas G.

AU - McGue, Matt

AU - McMahon, George

AU - Pedersen, Nancy L.

AU - Pinker, Steven

AU - Porteous, David J.

AU - Posthuma, Danielle

AU - Rivadeneira, Fernando

AU - Smithk, Blair H.

AU - Starr, John M.

AU - Tiemeier, Henning

AU - Timpsonm, Nicholas J.

AU - Trzaskowskin, Maciej

AU - Uitterlinden, André G.

AU - Verhulst, Frank C.

AU - Ward, Mary E.

AU - Wright, Margaret J.

AU - Smith, George Davey

AU - Deary, Ian J.

AU - Johannesson, Magnus

AU - Plomin, Robert

AU - Visscher, Peter M.

AU - Benjamin, Daniel J.

AU - Cesarini, David

AU - Koellinger, Philipp D.

PY - 2014/9/23

Y1 - 2014/9/23

N2 - We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.

AB - We identify common genetic variants associated with cognitive performance using a two-stage approach, which we call the proxyphenotype method. First, we conduct a genome-wide association study of educational attainment in a large sample (n = 106,736), which produces a set of 69 education-associated SNPs. Second, using independent samples (n = 24,189), we measure the association of these education-associated SNPs with cognitive performance. Three SNPs (rs1487441, rs7923609, and rs2721173) are significantly associated with cognitive performance after correction for multiple hypothesis testing. In an independent sample of older Americans (n = 8,652), we also show that a polygenic score derived from the education-associated SNPs is associated with memory and absence of dementia. Convergent evidence from a set of bioinformatics analyses implicates four specific genes (KNCMA1, NRXN1, POU2F3, and SCRT). All of these genes are associated with a particular neurotransmitter pathway involved in synaptic plasticity, the main cellular mechanism for learning and memory.

UR - http://www.scopus.com/inward/record.url?scp=84907285601&partnerID=8YFLogxK

U2 - 10.1073/pnas.1404623111

DO - 10.1073/pnas.1404623111

M3 - Article (Academic Journal)

C2 - 25201988

AN - SCOPUS:84907285601

VL - 111

SP - 13790

EP - 13794

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 38

ER -

Common genetic variants associated with cognitive performance identified using the proxy-phenotype method

Abstract

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MRC UoB UNITE Unit - programme 3

MRC UoB UNITE Unit - Programme 1

EXTENSION OF RD1321 VIA IOP.

Professor George Davey Smith

Cite this