Common genetic variants influence human subcortical brain structures

Derrek P Hibar, Jason L Stein, Miguel E Renteria, Alejandro Arias-Vasquez, Sylvane Desrivières, Neda Jahanshad, Roberto Toro, Katharina Wittfeld, Lucija Abramovic, Micael Andersson, Benjamin S Aribisala, Nicola J Armstrong, Manon Bernard, Marc M Bohlken, Marco P Boks, Janita Bralten, Andrew A Brown, M Mallar Chakravarty, Qiang Chen, Christopher R K ChingGabriel Cuellar-Partida, Anouk den Braber, Sudheer Giddaluru, Aaron L Goldman, Oliver Grimm, Tulio Guadalupe, Johanna Hass, Girma Woldehawariat, Avram J Holmes, Martine Hoogman, Deborah Janowitz, Tianye Jia, Sungeun Kim, Marieke Klein, Bernd Kraemer, Phil H Lee, Loes M Olde Loohuis, Michelle Luciano, Emma J Rose, Esther Walton, Robert C Green, Mark Jenkinson, Colin Smith, Jessica A Turner, Robert W Williams, Gareth E Davies, John Hardy, Zdenka Pausova, Paul M Thompson, Sarah E Medland, Alzheimer’s Disease Neuroimaging Initiative

Research output: Contribution to journalArticle (Academic Journal)

400 Citations (Scopus)

Abstract

The highly complex structure of the human brain is strongly shaped by genetic influences. Subcortical brain regions form circuits with cortical areas to coordinate movement, learning, memory and motivation, and altered circuits can lead to abnormal behaviour and disease. To investigate how common genetic variants affect the structure of these brain regions, here we conduct genome-wide association studies of the volumes of seven subcortical regions and the intracranial volume derived from magnetic resonance images of 30,717 individuals from 50 cohorts. We identify five novel genetic variants influencing the volumes of the putamen and caudate nucleus. We also find stronger evidence for three loci with previously established influences on hippocampal volume and intracranial volume. These variants show specific volumetric effects on brain structures rather than global effects across structures. The strongest effects were found for the putamen, where a novel intergenic locus with replicable influence on volume (rs945270; P = 1.08 × 10(-33); 0.52% variance explained) showed evidence of altering the expression of the KTN1 gene in both brain and blood tissue. Variants influencing putamen volume clustered near developmental genes that regulate apoptosis, axon guidance and vesicle transport. Identification of these genetic variants provides insight into the causes of variability in human brain development, and may help to determine mechanisms of neuropsychiatric dysfunction.

Original languageEnglish
Pages (from-to)224-9
Number of pages6
JournalNature
Volume520
Issue number7546
DOIs
Publication statusPublished - 9 Apr 2015

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Aging
  • Apoptosis
  • Brain
  • Caudate Nucleus
  • Child
  • Female
  • Gene Expression Regulation, Developmental
  • Genetic Loci
  • Genetic Variation
  • Genome-Wide Association Study
  • Hippocampus
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Membrane Proteins
  • Middle Aged
  • Organ Size
  • Putamen
  • Sex Characteristics
  • Skull
  • Young Adult

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  • Cite this

    Hibar, D. P., Stein, J. L., Renteria, M. E., Arias-Vasquez, A., Desrivières, S., Jahanshad, N., Toro, R., Wittfeld, K., Abramovic, L., Andersson, M., Aribisala, B. S., Armstrong, N. J., Bernard, M., Bohlken, M. M., Boks, M. P., Bralten, J., Brown, A. A., Chakravarty, M. M., Chen, Q., ... Alzheimer’s Disease Neuroimaging Initiative (2015). Common genetic variants influence human subcortical brain structures. Nature, 520(7546), 224-9. https://doi.org/10.1038/nature14101