Common genetic variations in telomere length genes and lung cancer:: a Mendelian randomisation study and its novel application in lung tumour transcriptome

Ricardo C. C. Penha; Philip C Haycock; Siddhartha Kar

doi:10.7554/eLife.83118

Common genetic variations in telomere length genes and lung cancer: a Mendelian randomisation study and its novel application in lung tumour transcriptome

Ricardo C. C. Penha, Philip C Haycock, Siddhartha Kar

Research output: Contribution to journal › Article (Academic Journal) › peer-review

11 Citations (Scopus)

66 Downloads (Pure)

Original language	English
Article number	e83118
Journal	eLife
Volume	12
DOIs	https://doi.org/10.7554/eLife.83118
Publication status	Published - 20 Apr 2023

Bibliographical note

Funding Information:
We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1-[TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France Génomique National infrastructure, funded as part of the « Investisse-ments d’Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas (RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019).

Funding Information:
We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1 - [TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France Génomique National infrastructure, funded as part of the « Investisse-ments d’Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas ( RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019).

Publisher Copyright:
© 2023, eLife Sciences Publications Ltd. All rights reserved.

Research Groups and Themes

ICEP

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.7554/eLife.83118Licence: CC BY

elife-83118-v1Final published version, 3.91 MBLicence: CC BY

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Persistent link

8074 (C18281/A29019) ICEP2 - Programme Award: Towards improved casual evidence and enhanced prediction of cancer risk and survival
Martin, R. M. (Principal Investigator)
1/10/20 → 30/09/25
Project: Research

Cite this

@article{68a0cd092e2f4464a81793d7565ac79b,

title = "Common genetic variations in telomere length genes and lung cancer:: a Mendelian randomisation study and its novel application in lung tumour transcriptome",

author = "Penha, {Ricardo C. C.} and Haycock, {Philip C} and Siddhartha Kar",

note = "Funding Information: We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1-[TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France G{\'e}nomique National infrastructure, funded as part of the « Investisse-ments d{\textquoteright}Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas (RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019). Funding Information: We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1 - [TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France G{\'e}nomique National infrastructure, funded as part of the « Investisse-ments d{\textquoteright}Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas ( RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019). Publisher Copyright: {\textcopyright} 2023, eLife Sciences Publications Ltd. All rights reserved.",

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AU - Kar, Siddhartha

N1 - Funding Information: We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1-[TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France Génomique National infrastructure, funded as part of the « Investisse-ments d’Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas (RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019). Funding Information: We would like to acknowledge the TCGA Research Network (https://www.cancer.gov/tcga) and the contribution of specimen donors and research groups involved in this resource. We also would like to acknowledge the ILCCO consortium, the participants of the UK biobank and GTEx project and the supporting bodies (https://commonfund.nih.gov/GTEx), specimen donors, and research groups. This work was supported by the Institut National du Cancer (INCa) (GeniLuc 2017–1-TABAC-03-CIRC-1 - [TABAC 17‐022]), NIH/NCI, INTEGRAL NIH 5U19CA203654-03, Cancer Research UK (grant number C18281/A29019), the France Génomique National infrastructure, funded as part of the « Investisse-ments d’Avenir » program managed by the Agence Nationale pour la Recherche (contract ANR-10-INBS-09). Christopher Amos is a Research Scholar of the Cancer Prevention Institute of Texas ( RR170048). The work of Ricardo Cortez Cardoso Penha reported in this paper was undertaken during the tenure of an IARC Postdoctoral Fellowship at the International Agency for Research on Cancer. Linda Kachuri is supported by funding from the National Institutes of Health (K99CA246076). Philip Haycock is supported by funding from Cancer Research UK (C18281/A29019). Publisher Copyright: © 2023, eLife Sciences Publications Ltd. All rights reserved.

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