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Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways

Research output: Contribution to journalArticle

  • Nicole Soranzo
  • Serena Sanna
  • Eleanor Wheeler
  • Christian Gieger
  • Dörte Radke
  • Josée Dupuis
  • Nabila Bouatia-Naji
  • Claudia Langenberg
  • Inga Prokopenko
  • Elliot Stolerman
  • Manjinder S Sandhu
  • Matthew M Heeney
  • Joseph M Devaney
  • Muredach P Reilly
  • Sally L Ricketts
  • Alexandre F R Stewart
  • Benjamin F Voight
  • Christina Willenborg
  • Benjamin Wright
  • David Altshuler
  • Dan Arking
  • Beverley Balkau
  • Daniel Barnes
  • Eric Boerwinkle
  • Bernhard Böhm
  • Amélie Bonnefond
  • Lori L Bonnycastle
  • Dorret I Boomsma
  • Stefan R Bornstein
  • Yvonne Böttcher
  • Suzannah Bumpstead
  • Mary Susan Burnett-Miller
  • Harry Campbell
  • Antonio Cao
  • John Chambers
  • Robert Clark
  • Francis S Collins
  • Josef Coresh
  • Eco J C de Geus
  • Mariano Dei
  • Panos Deloukas
  • Angela Döring
  • Josephine M Egan
  • Roberto Elosua
  • Luigi Ferrucci
  • Nita Forouhi
  • Caroline S Fox
  • Christopher Franklin
  • Maria Grazia Franzosi
  • Wendy L McArdle
Original languageEnglish
Pages (from-to)3229-39
Number of pages11
JournalDiabetic Medicine
Issue number12
DatePublished - 2010


Glycated hemoglobin (HbA₁(c)), used to monitor and diagnose diabetes, is influenced by average glycemia over a 2- to 3-month period. Genetic factors affecting expression, turnover, and abnormal glycation of hemoglobin could also be associated with increased levels of HbA₁(c). We aimed to identify such genetic factors and investigate the extent to which they influence diabetes classification based on HbA₁(c) levels.



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