Common variants in the region around Osterix are associated with bone mineral density and growth in childhood

Nicholas J Timpson, Jonathan H Tobias, J Brent Richards, Nicole Soranzo, Emma L Duncan, Anne-Marie Sims, Pamela Whittaker, Vasudev Kumanduri, Guangju Zhai, Beate Glaser, John Eisman, Graeme Jones, Geoff Nicholson, Richard Prince, Ego Seeman, Tim D Spector, Matthew A Brown, Leena Peltonen, George Davey Smith, Panos DeloukasDavid M Evans

Research output: Contribution to journalArticle (Academic Journal)peer-review

96 Citations (Scopus)

Abstract

Peak bone mass achieved in adolescence is a determinant of bone mass in later life. In order to identify genetic variants affecting bone mineral density (BMD), we performed a genome-wide association study of BMD and related traits in 1518 children from the Avon Longitudinal Study of Parents and Children (ALSPAC). We compared results with a scan of 134 adults with high or low hip BMD. We identified associations with BMD in an area of chromosome 12 containing the Osterix (SP7) locus, a transcription factor responsible for regulating osteoblast differentiation (ALSPAC: P = 5.8 x 10(-4); Australia: P = 3.7 x 10(-4)). This region has previously shown evidence of association with adult hip and lumbar spine BMD in an Icelandic population, as well as nominal association in a UK population. A meta-analysis of these existing studies revealed strong association between SNPs in the Osterix region and adult lumbar spine BMD (P = 9.9 x 10(-11)). In light of these findings, we genotyped a further 3692 individuals from ALSPAC who had whole body BMD and confirmed the association in children as well (P = 5.4 x 10(-5)). Moreover, all SNPs were related to height in ALSPAC children, but not weight or body mass index, and when height was included as a covariate in the regression equation, the association with total body BMD was attenuated. We conclude that genetic variants in the region of Osterix are associated with BMD in children and adults probably through primary effects on growth.
Translated title of the contributionCommon variants in the region around Osterix are associated with bone mineral density and growth in childhood
Original languageEnglish
Pages (from-to)1510 - 1517
Number of pages8
JournalHuman Molecular Genetics
Volume18
Issue number8
DOIs
Publication statusPublished - Apr 2009

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