Abstract
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.
Original language | English |
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Pages (from-to) | 197-199 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 42 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2010 |
Keywords
- Age Factors
- Aging
- Chromosomes, Human, Pair 3
- Cohort Studies
- Gene Frequency
- Genome-Wide Association Study
- Humans
- Meta-Analysis as Topic
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- RNA
- Telomerase
- Telomere
- Time Factors