Common variants near TERC are associated with mean telomere length

Veryan Codd, Massimo Mangino, Pim Van Der Harst, Peter S. Braund, Michael Kaiser, Alan J. Beveridge, Suzanne Rafelt, Jasbir Moore, Chris Nelson, Nicole Soranzo, Guangju Zhai, Ana M. Valdes, Hannah Blackburn, Irene Mateo Leach, Rudolf A. De Boer, Alison H. Goodall, Willem Ouwehand, Dirk J. Van Veldhuisen, Wiek H. Van Gilst, Gerjan NavisPaul R. Burton, Martin D. Tobin, Alistair S. Hall, John R. Thompson, Tim Spector, Nilesh J. Samani

Research output: Contribution to journalArticle (Academic Journal)peer-review

229 Citations (Scopus)

Abstract

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.

Original languageEnglish
Pages (from-to)197-199
Number of pages3
JournalNature Genetics
Volume42
Issue number3
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Age Factors
  • Aging
  • Chromosomes, Human, Pair 3
  • Cohort Studies
  • Gene Frequency
  • Genome-Wide Association Study
  • Humans
  • Meta-Analysis as Topic
  • Polymorphism, Single Nucleotide
  • Quantitative Trait Loci
  • RNA
  • Telomerase
  • Telomere
  • Time Factors

Fingerprint Dive into the research topics of 'Common variants near TERC are associated with mean telomere length'. Together they form a unique fingerprint.

Cite this