Common variants near TERC are associated with mean telomere length

Veryan Codd; Massimo Mangino; Pim Van Der Harst; Peter S. Braund; Michael Kaiser; Alan J. Beveridge; Suzanne Rafelt; Jasbir Moore; Chris Nelson; Nicole Soranzo; Guangju Zhai; Ana M. Valdes; Hannah Blackburn; Irene Mateo Leach; Rudolf A. De Boer; Alison H. Goodall; Willem Ouwehand; Dirk J. Van Veldhuisen; Wiek H. Van Gilst; Gerjan Navis; Paul R. Burton; Martin D. Tobin; Alistair S. Hall; John R. Thompson; Tim Spector; Nilesh J. Samani

doi:10.1038/ng.532

Common variants near TERC are associated with mean telomere length

Veryan Codd, Massimo Mangino, Pim Van Der Harst, Peter S. Braund, Michael Kaiser, Alan J. Beveridge, Suzanne Rafelt, Jasbir Moore, Chris Nelson, Nicole Soranzo, Guangju Zhai, Ana M. Valdes, Hannah Blackburn, Irene Mateo Leach, Rudolf A. De Boer, Alison H. Goodall, Willem Ouwehand, Dirk J. Van Veldhuisen, Wiek H. Van Gilst, Gerjan NavisPaul R. Burton, Martin D. Tobin, Alistair S. Hall, John R. Thompson, Tim Spector, Nilesh J. Samani

Bristol Medical School (PHS)

Research output: Contribution to journal › Article (Academic Journal) › peer-review

248 Citations (Scopus)

Abstract

We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.

Original language	English
Pages (from-to)	197-199
Number of pages	3
Journal	Nature Genetics
Volume	42
Issue number	3
DOIs	https://doi.org/10.1038/ng.532
Publication status	Published - Mar 2010

Keywords

Age Factors
Aging
Chromosomes, Human, Pair 3
Cohort Studies
Gene Frequency
Genome-Wide Association Study
Humans
Meta-Analysis as Topic
Polymorphism, Single Nucleotide
Quantitative Trait Loci
RNA
Telomerase
Telomere
Time Factors

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Codd, V., Mangino, M., Van Der Harst, P., Braund, P. S., Kaiser, M., Beveridge, A. J., Rafelt, S., Moore, J., Nelson, C., Soranzo, N., Zhai, G., Valdes, A. M., Blackburn, H., Leach, I. M., De Boer, R. A., Goodall, A. H., Ouwehand, W., Van Veldhuisen, D. J., Van Gilst, W. H., ... Samani, N. J. (2010). Common variants near TERC are associated with mean telomere length. Nature Genetics, 42(3), 197-199. https://doi.org/10.1038/ng.532

Codd, Veryan ; Mangino, Massimo ; Van Der Harst, Pim ; Braund, Peter S. ; Kaiser, Michael ; Beveridge, Alan J. ; Rafelt, Suzanne ; Moore, Jasbir ; Nelson, Chris ; Soranzo, Nicole ; Zhai, Guangju ; Valdes, Ana M. ; Blackburn, Hannah ; Leach, Irene Mateo ; De Boer, Rudolf A. ; Goodall, Alison H. ; Ouwehand, Willem ; Van Veldhuisen, Dirk J. ; Van Gilst, Wiek H. ; Navis, Gerjan ; Burton, Paul R. ; Tobin, Martin D. ; Hall, Alistair S. ; Thompson, John R. ; Spector, Tim ; Samani, Nilesh J. / Common variants near TERC are associated with mean telomere length. In: Nature Genetics. 2010 ; Vol. 42, No. 3. pp. 197-199.

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title = "Common variants near TERC are associated with mean telomere length",

abstract = "We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately 75-base-pair reduction in mean telomere length, equivalent to approximately 3.6 years of age-related telomere-length attrition.",

keywords = "Age Factors, Aging, Chromosomes, Human, Pair 3, Cohort Studies, Gene Frequency, Genome-Wide Association Study, Humans, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Quantitative Trait Loci, RNA, Telomerase, Telomere, Time Factors",

author = "Veryan Codd and Massimo Mangino and {Van Der Harst}, Pim and Braund, {Peter S.} and Michael Kaiser and Beveridge, {Alan J.} and Suzanne Rafelt and Jasbir Moore and Chris Nelson and Nicole Soranzo and Guangju Zhai and Valdes, {Ana M.} and Hannah Blackburn and Leach, {Irene Mateo} and {De Boer}, {Rudolf A.} and Goodall, {Alison H.} and Willem Ouwehand and {Van Veldhuisen}, {Dirk J.} and {Van Gilst}, {Wiek H.} and Gerjan Navis and Burton, {Paul R.} and Tobin, {Martin D.} and Hall, {Alistair S.} and Thompson, {John R.} and Tim Spector and Samani, {Nilesh J.}",

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pages = "197--199",

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Codd, V, Mangino, M, Van Der Harst, P, Braund, PS, Kaiser, M, Beveridge, AJ, Rafelt, S, Moore, J, Nelson, C, Soranzo, N, Zhai, G, Valdes, AM, Blackburn, H, Leach, IM, De Boer, RA, Goodall, AH, Ouwehand, W, Van Veldhuisen, DJ, Van Gilst, WH, Navis, G, Burton, PR, Tobin, MD, Hall, AS, Thompson, JR, Spector, T & Samani, NJ 2010, 'Common variants near TERC are associated with mean telomere length', Nature Genetics, vol. 42, no. 3, pp. 197-199. https://doi.org/10.1038/ng.532

Common variants near TERC are associated with mean telomere length. / Codd, Veryan; Mangino, Massimo; Van Der Harst, Pim; Braund, Peter S.; Kaiser, Michael; Beveridge, Alan J.; Rafelt, Suzanne; Moore, Jasbir; Nelson, Chris; Soranzo, Nicole; Zhai, Guangju; Valdes, Ana M.; Blackburn, Hannah; Leach, Irene Mateo; De Boer, Rudolf A.; Goodall, Alison H.; Ouwehand, Willem; Van Veldhuisen, Dirk J.; Van Gilst, Wiek H.; Navis, Gerjan; Burton, Paul R.; Tobin, Martin D.; Hall, Alistair S.; Thompson, John R.; Spector, Tim; Samani, Nilesh J.

In: Nature Genetics, Vol. 42, No. 3, 03.2010, p. 197-199.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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KW - Genome-Wide Association Study

KW - Humans

KW - Meta-Analysis as Topic

KW - Polymorphism, Single Nucleotide

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DO - 10.1038/ng.532

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JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 3

ER -

Common variants near TERC are associated with mean telomere length

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