Comparative immunochemical analysis of Wra and Wrb red cell antigens

S M Ring, P Tippett, D M Swallow

Research output: Contribution to journalArticle (Academic Journal)peer-review

19 Citations (Scopus)

Abstract

This paper describes immunoblotting and immunoprecipitation studies using monoclonal anti-Wra and anti-Wrb antibodies to investigate the nature of the low-incidence blood group antigen, Wra and its high-incidence allelic antigen Wrb. No membrane components were identified by the immunoblotting experiments. Immunoprecipitation studies confirmed that the Wrb antigen involves both glycophorin A and band 3. The monoclonal anti-Wra, BGU1-WR, failed to immunoprecipitate these or any othe red cell membrane component. The significance of these findings is discussed.

Original languageEnglish
Pages (from-to)226-30
Number of pages5
JournalVox sanguinis
Volume67
Issue number2
Publication statusPublished - 1994

Keywords

  • Alleles
  • Antibodies, Monoclonal
  • Erythrocytes
  • Humans
  • Immunoblotting
  • Incidence
  • Isoantigens
  • Precipitin Tests

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