Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial

Karen M Beaver; S. Williamson; C Sutton; W. Hollingworth; A Gardner; B. Allton; M. Abdel-Aty; K. Blackwood; S. Burns; D. Curwen; R. Ghani; P. Keating; Stephen S. Murray; A. Tomlinson; B Walker; M. Willett; Neil Wood; P. Martin-Hirsch

doi:10.1111/1471-0528.14000

Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial

Karen M Beaver^*, S. Williamson, C Sutton, W. Hollingworth, A Gardner, B. Allton, M. Abdel-Aty, K. Blackwood, S. Burns, D. Curwen, R. Ghani, P. Keating, Stephen S. Murray, A. Tomlinson, B Walker, M. Willett, Neil Wood, P. Martin-Hirsch

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Objective: To evaluate the effectiveness of nurse-led telephone follow-up (TFU) for patients with stage-I endometrial cancer.

Design: Multicentre, randomised, non-inferiority trial.

Setting: Five centres in the North West of England.

Sample: A cohort of 259 women treated for stage-I endometrial cancer attending hospital outpatient clinics for routine follow-up.

Methods: Participants were randomly allocated to receive traditional hospital based follow-up (HFU) or nurse-led TFU.

Main outcome measures: Primary outcomes were psychological morbidity (State Trait Anxiety Inventory, STAI-S) and patient satisfaction with the information provided. Secondary outcomes included patient satisfaction with service, quality of life, and time to detection of recurrence.

Results: The STAI-S scores post-randomisation were similar between groups [mean (SD): TFU 33.0 (11.0); HFU 35.5 (13.0)]. The estimated between-group difference in STAI-S was 0.7 (95% confidence interval, 95% CI -1.9 to 3.3); the confidence interval lies above the non-inferiority limit (-3.5), indicating the non-inferiority of TFU. There was no significant difference between groups in reported satisfaction with information (odds ratio, OR 0.9; 95% CI 0.4-2.1; P = 0.83). Women in the HFU group were more likely to report being kept waiting for their appointment (P = 0.001), that they did not need any information (P = 0.003), and were less likely to report that the nurse knew about their particular case and situation (P = 0.005).

Conclusions: The TFU provides an effective alternative to HFU for patients with stage-I endometrial cancer, with no reported physical or psychological detriment. Patient satisfaction with information was high, with similar levels between groups.

Tweetable abstract: ENDCAT trial shows effectiveness of nurse-led telephone follow-up for patients with stage-I endometrial cancer.

Original language	English
Pages (from-to)	150-160
Number of pages	11
Journal	BJOG: An International Journal of Obstetrics and Gynaecology
Volume	124
Issue number	1
Early online date	7 Apr 2016
DOIs	https://doi.org/10.1111/1471-0528.14000
Publication status	Published - Jan 2017

Keywords

Endometrial cancer
Gynaecology
Morbidity
Oncology
Patient satisfaction
Psychological
Telephone follow-up

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10.1111/1471-0528.14000

Full-text PDF (accepted author manuscript)
This is the author accepted manuscript (AAM). The final published version (version of record) is available online via SAGE at http://dx.doi.org/10.1111/1471-0528.14000. Please refer to any applicable terms of use of the publisher.
Accepted author manuscript, 382 KB
ENDCAT CONSORT Flow Diagram Figure 1 V2Other version, 269 KB
Table 1 ENDCATOther version, 103 KB
Table 2 ENDCATOther version, 193 KB
Table 3 ENDCAT

Cite this

Beaver, K. M., Williamson, S., Sutton, C., Hollingworth, W., Gardner, A., Allton, B., Abdel-Aty, M., Blackwood, K., Burns, S., Curwen, D., Ghani, R., Keating, P., Murray, S. S., Tomlinson, A., Walker, B., Willett, M., Wood, N., & Martin-Hirsch, P. (2017). Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial. BJOG: An International Journal of Obstetrics and Gynaecology, 124(1), 150-160. https://doi.org/10.1111/1471-0528.14000

Beaver, Karen M ; Williamson, S. ; Sutton, C ; Hollingworth, W. ; Gardner, A ; Allton, B. ; Abdel-Aty, M. ; Blackwood, K. ; Burns, S. ; Curwen, D. ; Ghani, R. ; Keating, P. ; Murray, Stephen S. ; Tomlinson, A. ; Walker, B ; Willett, M. ; Wood, Neil ; Martin-Hirsch, P. / Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial) : A randomised, multicentre, non-inferiority trial. In: BJOG: An International Journal of Obstetrics and Gynaecology. 2017 ; Vol. 124, No. 1. pp. 150-160.

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title = "Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial",

abstract = "Objective: To evaluate the effectiveness of nurse-led telephone follow-up (TFU) for patients with stage-I endometrial cancer. Design: Multicentre, randomised, non-inferiority trial. Setting: Five centres in the North West of England. Sample: A cohort of 259 women treated for stage-I endometrial cancer attending hospital outpatient clinics for routine follow-up. Methods: Participants were randomly allocated to receive traditional hospital based follow-up (HFU) or nurse-led TFU. Main outcome measures: Primary outcomes were psychological morbidity (State Trait Anxiety Inventory, STAI-S) and patient satisfaction with the information provided. Secondary outcomes included patient satisfaction with service, quality of life, and time to detection of recurrence. Results: The STAI-S scores post-randomisation were similar between groups [mean (SD): TFU 33.0 (11.0); HFU 35.5 (13.0)]. The estimated between-group difference in STAI-S was 0.7 (95% confidence interval, 95% CI -1.9 to 3.3); the confidence interval lies above the non-inferiority limit (-3.5), indicating the non-inferiority of TFU. There was no significant difference between groups in reported satisfaction with information (odds ratio, OR 0.9; 95% CI 0.4-2.1; P = 0.83). Women in the HFU group were more likely to report being kept waiting for their appointment (P = 0.001), that they did not need any information (P = 0.003), and were less likely to report that the nurse knew about their particular case and situation (P = 0.005). Conclusions: The TFU provides an effective alternative to HFU for patients with stage-I endometrial cancer, with no reported physical or psychological detriment. Patient satisfaction with information was high, with similar levels between groups. Tweetable abstract: ENDCAT trial shows effectiveness of nurse-led telephone follow-up for patients with stage-I endometrial cancer.",

keywords = "Endometrial cancer, Gynaecology, Morbidity, Oncology, Patient satisfaction, Psychological, Telephone follow-up",

author = "Beaver, {Karen M} and S. Williamson and C Sutton and W. Hollingworth and A Gardner and B. Allton and M. Abdel-Aty and K. Blackwood and S. Burns and D. Curwen and R. Ghani and P. Keating and Murray, {Stephen S.} and A. Tomlinson and B Walker and M. Willett and Neil Wood and P. Martin-Hirsch",

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Beaver, KM, Williamson, S, Sutton, C, Hollingworth, W, Gardner, A, Allton, B, Abdel-Aty, M, Blackwood, K, Burns, S, Curwen, D, Ghani, R, Keating, P, Murray, SS, Tomlinson, A, Walker, B, Willett, M, Wood, N & Martin-Hirsch, P 2017, 'Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial', BJOG: An International Journal of Obstetrics and Gynaecology, vol. 124, no. 1, pp. 150-160. https://doi.org/10.1111/1471-0528.14000

Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial) : A randomised, multicentre, non-inferiority trial. / Beaver, Karen M; Williamson, S.; Sutton, C; Hollingworth, W.; Gardner, A; Allton, B.; Abdel-Aty, M.; Blackwood, K.; Burns, S.; Curwen, D.; Ghani, R.; Keating, P.; Murray, Stephen S.; Tomlinson, A.; Walker, B; Willett, M.; Wood, Neil; Martin-Hirsch, P.

In: BJOG: An International Journal of Obstetrics and Gynaecology, Vol. 124, No. 1, 01.2017, p. 150-160.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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T1 - Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial)

T2 - A randomised, multicentre, non-inferiority trial

AU - Beaver, Karen M

AU - Williamson, S.

AU - Sutton, C

AU - Hollingworth, W.

AU - Gardner, A

AU - Allton, B.

AU - Abdel-Aty, M.

AU - Blackwood, K.

AU - Burns, S.

AU - Curwen, D.

AU - Ghani, R.

AU - Keating, P.

AU - Murray, Stephen S.

AU - Tomlinson, A.

AU - Walker, B

AU - Willett, M.

AU - Wood, Neil

AU - Martin-Hirsch, P.

PY - 2017/1

Y1 - 2017/1

N2 - Objective: To evaluate the effectiveness of nurse-led telephone follow-up (TFU) for patients with stage-I endometrial cancer. Design: Multicentre, randomised, non-inferiority trial. Setting: Five centres in the North West of England. Sample: A cohort of 259 women treated for stage-I endometrial cancer attending hospital outpatient clinics for routine follow-up. Methods: Participants were randomly allocated to receive traditional hospital based follow-up (HFU) or nurse-led TFU. Main outcome measures: Primary outcomes were psychological morbidity (State Trait Anxiety Inventory, STAI-S) and patient satisfaction with the information provided. Secondary outcomes included patient satisfaction with service, quality of life, and time to detection of recurrence. Results: The STAI-S scores post-randomisation were similar between groups [mean (SD): TFU 33.0 (11.0); HFU 35.5 (13.0)]. The estimated between-group difference in STAI-S was 0.7 (95% confidence interval, 95% CI -1.9 to 3.3); the confidence interval lies above the non-inferiority limit (-3.5), indicating the non-inferiority of TFU. There was no significant difference between groups in reported satisfaction with information (odds ratio, OR 0.9; 95% CI 0.4-2.1; P = 0.83). Women in the HFU group were more likely to report being kept waiting for their appointment (P = 0.001), that they did not need any information (P = 0.003), and were less likely to report that the nurse knew about their particular case and situation (P = 0.005). Conclusions: The TFU provides an effective alternative to HFU for patients with stage-I endometrial cancer, with no reported physical or psychological detriment. Patient satisfaction with information was high, with similar levels between groups. Tweetable abstract: ENDCAT trial shows effectiveness of nurse-led telephone follow-up for patients with stage-I endometrial cancer.

AB - Objective: To evaluate the effectiveness of nurse-led telephone follow-up (TFU) for patients with stage-I endometrial cancer. Design: Multicentre, randomised, non-inferiority trial. Setting: Five centres in the North West of England. Sample: A cohort of 259 women treated for stage-I endometrial cancer attending hospital outpatient clinics for routine follow-up. Methods: Participants were randomly allocated to receive traditional hospital based follow-up (HFU) or nurse-led TFU. Main outcome measures: Primary outcomes were psychological morbidity (State Trait Anxiety Inventory, STAI-S) and patient satisfaction with the information provided. Secondary outcomes included patient satisfaction with service, quality of life, and time to detection of recurrence. Results: The STAI-S scores post-randomisation were similar between groups [mean (SD): TFU 33.0 (11.0); HFU 35.5 (13.0)]. The estimated between-group difference in STAI-S was 0.7 (95% confidence interval, 95% CI -1.9 to 3.3); the confidence interval lies above the non-inferiority limit (-3.5), indicating the non-inferiority of TFU. There was no significant difference between groups in reported satisfaction with information (odds ratio, OR 0.9; 95% CI 0.4-2.1; P = 0.83). Women in the HFU group were more likely to report being kept waiting for their appointment (P = 0.001), that they did not need any information (P = 0.003), and were less likely to report that the nurse knew about their particular case and situation (P = 0.005). Conclusions: The TFU provides an effective alternative to HFU for patients with stage-I endometrial cancer, with no reported physical or psychological detriment. Patient satisfaction with information was high, with similar levels between groups. Tweetable abstract: ENDCAT trial shows effectiveness of nurse-led telephone follow-up for patients with stage-I endometrial cancer.

KW - Endometrial cancer

KW - Gynaecology

KW - Morbidity

KW - Oncology

KW - Patient satisfaction

KW - Psychological

KW - Telephone follow-up

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DO - 10.1111/1471-0528.14000

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C2 - 27062690

AN - SCOPUS:84963787999

VL - 124

SP - 150

EP - 160

JO - BJOG: An International Journal of Obstetrics and Gynaecology

JF - BJOG: An International Journal of Obstetrics and Gynaecology

SN - 1470-0328

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ER -

Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial

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Comparing hospital and telephone follow-up for patients treated for stage-I endometrial cancer (ENDCAT trial): A randomised, multicentre, non-inferiority trial

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