Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.

Jiayi   Zheng; Monika R Frysz; Ben G Faber; Huandong   Lin; Raja Ebsim; Jieyu  Ge; Yanling  Yong; Fiona R.  Saunders; Jennifer S.  Gregory; Richard M.  Aspden; Nicholas C.  Harvey; Bing-Hua  Jiang; Timothy   Cootes; Claudia  Lindner; Xin  Gao; Sijia   Wang; Jonathan H Tobias

doi:10.1016/j.joca.2023.10.006

Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.

Jiayi Zheng, Monika R Frysz, Ben G Faber, Huandong Lin, Raja Ebsim, Jieyu Ge, Yanling Yong, Fiona R. Saunders, Jennifer S. Gregory, Richard M. Aspden, Nicholas C. Harvey, Bing-Hua Jiang, Timothy Cootes, Claudia Lindner, Xin Gao^*, Sijia Wang^*, Jonathan H Tobias^*

^*Corresponding author for this work

Research output: Contribution to journal › Article (Academic Journal) › peer-review

3 Citations (Scopus)

Abstract

Objects
Joint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.

Methods
Left hip iDXA scans were used to quantify rHOA, from a combination of osteophytes (grade ≥1) and joint space narrowing (grade ≥1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle ≥60°) and pincer (lateral centre-edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of femoral head (DFH), femoral neck width (FNW), and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height, and weight and stratified by sex.

Results
Complete data were available for 5924 SC and 39,020 White UKB participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.

Conclusions
rHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.

Original language	English
Journal	Osteoarthritis and Cartilage
Early online date	5 Nov 2023
DOIs	https://doi.org/10.1016/j.joca.2023.10.006
Publication status	E-pub ahead of print - 5 Nov 2023

Bibliographical note

Funding Information:
This research was conducted using the UK Biobank Resource (application number 17295). It was funded in part by the Wellcome Trust (Grant No. 209233 ), which provided salary support for MF, FS and RE. SW is supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDB38020400 ), the CAS Project for Young Scientists in Basic Research (Grant No. YSBR-077 ), Shanghai Science and Technology Commission Excellent Academic Leaders Program ( 22XD1424700 ) and Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ). BGF is a National Institute of Health and Care Research Academic Clinical Lecturer and was previously supported by a Medical Research Council ( MRC ) clinical research training fellowship ( MR/ S021280/1 ). CL is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society ( 223267/Z/21/Z ). NCH is supported by the UK Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001]. XG is supported by Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ).

Publisher Copyright:
© 2023 The Authors

Access to Document

10.1016/j.joca.2023.10.006Licence: CC BY

Handle.net

Persistent link

Cite this

Zheng, J., Frysz, M. R., Faber, B. G., Lin, H., Ebsim, R., Ge, J., Yong, Y., Saunders, F. R., Gregory, J. S., Aspden, R. M., Harvey, N. C., Jiang, B.-H., Cootes, T., Lindner, C., Gao, X., Wang, S., & Tobias, J. H. (2023). Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis. Osteoarthritis and Cartilage. Advance online publication. https://doi.org/10.1016/j.joca.2023.10.006

@article{f75323dc6f624c4aacfe2ed3293eb095,

title = "Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.",

abstract = "ObjectsJoint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.MethodsLeft hip iDXA scans were used to quantify rHOA, from a combination of osteophytes (grade ≥1) and joint space narrowing (grade ≥1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle ≥60°) and pincer (lateral centre-edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of femoral head (DFH), femoral neck width (FNW), and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height, and weight and stratified by sex.ResultsComplete data were available for 5924 SC and 39,020 White UKB participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.ConclusionsrHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.",

author = "Jiayi Zheng and Frysz, {Monika R} and Faber, {Ben G} and Huandong Lin and Raja Ebsim and Jieyu Ge and Yanling Yong and Saunders, {Fiona R.} and Gregory, {Jennifer S.} and Aspden, {Richard M.} and Harvey, {Nicholas C.} and Bing-Hua Jiang and Timothy Cootes and Claudia Lindner and Xin Gao and Sijia Wang and Tobias, {Jonathan H}",

note = "Funding Information: This research was conducted using the UK Biobank Resource (application number 17295). It was funded in part by the Wellcome Trust (Grant No. 209233 ), which provided salary support for MF, FS and RE. SW is supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDB38020400 ), the CAS Project for Young Scientists in Basic Research (Grant No. YSBR-077 ), Shanghai Science and Technology Commission Excellent Academic Leaders Program ( 22XD1424700 ) and Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ). BGF is a National Institute of Health and Care Research Academic Clinical Lecturer and was previously supported by a Medical Research Council ( MRC ) clinical research training fellowship ( MR/ S021280/1 ). CL is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society ( 223267/Z/21/Z ). NCH is supported by the UK Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001]. XG is supported by Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ). Publisher Copyright: {\textcopyright} 2023 The Authors",

year = "2023",

month = nov,

day = "5",

doi = "10.1016/j.joca.2023.10.006",

language = "English",

journal = "Osteoarthritis and Cartilage",

issn = "1063-4584",

publisher = "W.B. Saunders",

}

Zheng, J, Frysz, MR, Faber, BG, Lin, H, Ebsim, R, Ge, J, Yong, Y, Saunders, FR, Gregory, JS, Aspden, RM, Harvey, NC, Jiang, B-H, Cootes, T, Lindner, C, Gao, X, Wang, S & Tobias, JH 2023, 'Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.', Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2023.10.006

TY - JOUR

T1 - Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.

AU - Zheng, Jiayi

AU - Frysz, Monika R

AU - Faber, Ben G

AU - Lin, Huandong

AU - Ebsim, Raja

AU - Ge, Jieyu

AU - Yong, Yanling

AU - Saunders, Fiona R.

AU - Gregory, Jennifer S.

AU - Aspden, Richard M.

AU - Harvey, Nicholas C.

AU - Jiang, Bing-Hua

AU - Cootes, Timothy

AU - Lindner, Claudia

AU - Gao, Xin

AU - Wang, Sijia

AU - Tobias, Jonathan H

N1 - Funding Information: This research was conducted using the UK Biobank Resource (application number 17295). It was funded in part by the Wellcome Trust (Grant No. 209233 ), which provided salary support for MF, FS and RE. SW is supported by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDB38020400 ), the CAS Project for Young Scientists in Basic Research (Grant No. YSBR-077 ), Shanghai Science and Technology Commission Excellent Academic Leaders Program ( 22XD1424700 ) and Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ). BGF is a National Institute of Health and Care Research Academic Clinical Lecturer and was previously supported by a Medical Research Council ( MRC ) clinical research training fellowship ( MR/ S021280/1 ). CL is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society ( 223267/Z/21/Z ). NCH is supported by the UK Medical Research Council (MRC) [MC_PC_21003; MC_PC_21001]. XG is supported by Shanghai Municipal Science and Technology Major Project (Grant No. 2017SHZDZX01 ). Publisher Copyright: © 2023 The Authors

PY - 2023/11/5

Y1 - 2023/11/5

N2 - ObjectsJoint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.MethodsLeft hip iDXA scans were used to quantify rHOA, from a combination of osteophytes (grade ≥1) and joint space narrowing (grade ≥1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle ≥60°) and pincer (lateral centre-edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of femoral head (DFH), femoral neck width (FNW), and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height, and weight and stratified by sex.ResultsComplete data were available for 5924 SC and 39,020 White UKB participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.ConclusionsrHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.

AB - ObjectsJoint morphology is a risk factor for hip osteoarthritis (HOA) and could explain ethnic differences in HOA prevalence. Therefore, we aimed to compare the prevalence of radiographic HOA (rHOA) and hip morphology between the predominantly White UK Biobank (UKB) and exclusively Chinese Shanghai Changfeng (SC) cohorts.MethodsLeft hip iDXA scans were used to quantify rHOA, from a combination of osteophytes (grade ≥1) and joint space narrowing (grade ≥1), and hip morphology. Using an 85-point Statistical Shape Model (SSM) we evaluated cam (alpha angle ≥60°) and pincer (lateral centre-edge angle (LCEA) ≥45°) morphology and acetabular dysplasia (LCEA <25°). Diameter of femoral head (DFH), femoral neck width (FNW), and hip axis length (HAL) were also obtained from these points. Results were adjusted for differences in age, height, and weight and stratified by sex.ResultsComplete data were available for 5924 SC and 39,020 White UKB participants with mean ages of 63.4 and 63.7 years old. rHOA prevalence was considerably lower in female (2.2% versus 13.1%) and male (12.0% and 25.1%) SC compared to UKB participants. Cam morphology, rarely seen in females, was less common in SC compared with UKB males (6.3% versus 16.5%). Composite SSM modes, scaled to the same overall size, revealed SC participants to have a wider femoral head compared to UKB participants. FNW and HAL were smaller in SC compared to UKB, whereas DFH/FNW ratio was higher in SC.ConclusionsrHOA prevalence is lower in Chinese compared with White individuals. Several differences in hip shape were observed, including frequency of cam morphology, FNW, and DFH/FNW ratio. These characteristics have previously been identified as risk factors for HOA and may contribute to observed ethnic differences in HOA prevalence.

U2 - 10.1016/j.joca.2023.10.006

DO - 10.1016/j.joca.2023.10.006

M3 - Article (Academic Journal)

C2 - 37935324

SN - 1063-4584

JO - Osteoarthritis and Cartilage

JF - Osteoarthritis and Cartilage

ER -

Comparison between UK Biobank and Shanghai Changfeng suggests distinct hip morphology may contribute to ethnic differences in the prevalence of hip osteoarthritis.

Abstract

Bibliographical note

Access to Document

Handle.net

Fingerprint

Cite this