Comparison of methods for combining case-control and family-based association studies

Beate Glaser, Peter Holmans

Research output: Contribution to journalArticle (Academic Journal)peer-review

11 Citations (Scopus)

Abstract

Combining the analysis of family-based samples with unrelated individuals can enhance the power of genetic association studies. Various combined analysis techniques have been recently developed; as yet, there have been no comparisons of their power, or robustness to confounding factors. We investigated empirically the power of up to six combined methods using simulated samples of trios and unrelated cases/controls (TDTCC), trios and unrelated controls (TDTC), and affected sibpairs with parents and unrelated cases/controls (ASPFCC).
Original languageEnglish
Pages (from-to)106-16
Number of pages11
JournalHuman Heredity
Volume68
Issue number2
DOIs
Publication statusPublished - 2009

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