Abstract
Combining the analysis of family-based samples with unrelated individuals can enhance the power of genetic association studies. Various combined analysis techniques have been recently developed; as yet, there have been no comparisons of their power, or robustness to confounding factors. We investigated empirically the power of up to six combined methods using simulated samples of trios and unrelated cases/controls (TDTCC), trios and unrelated controls (TDTC), and affected sibpairs with parents and unrelated cases/controls (ASPFCC).
Original language | English |
---|---|
Pages (from-to) | 106-16 |
Number of pages | 11 |
Journal | Human Heredity |
Volume | 68 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2009 |