Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar; Roby Joehanes; Bonnie R Joubert; Cheng-Jian Xu; Marta Vives-Usano; Faisal I Rezwan; Janine F Felix; James M Ward; Weihua Guan; Rebecca C Richmond; Jennifer A Brody; Leanne K Kupers; Nour Baïz; Siri E Haberg; Jennifer A Smith; Sarah E. Reese; Stella Aslibekyan; Cathrine Hoyo; Radhika Dhingra; Christina A Markunas; Caroline L Relton; et al.

doi:10.2217/epi-2019-0066

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar, Roby Joehanes, Bonnie R Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I Rezwan, Janine F Felix, James M Ward, Weihua Guan, Rebecca C Richmond, Jennifer A Brody, Leanne K Kupers, Nour Baïz, Siri E Haberg, Jennifer A Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A MarkunasCaroline L Relton, et al.

Research output: Contribution to journal › Article (Academic Journal) › peer-review

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Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

Original language	English
Pages (from-to)	1487-1500
Number of pages	14
Journal	Epigenomics
Volume	11
Issue number	13
Early online date	19 Sept 2019
DOIs	https://doi.org/10.2217/epi-2019-0066
Publication status	E-pub ahead of print - 19 Sept 2019

Research Groups and Themes

ICEP

Keywords

cigarette smoking
epigenetics
infant
maternal exposure
methylation

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10.2217/epi-2019-0066

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This is the final published version of the article (version of record). It first appeared online via Future Medicine at https://www.futuremedicine.com/doi/10.2217/epi-2019-0066?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dwww.ncbi.nlm.nih.gov& . Please refer to any applicable terms of use of the publisher.
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IEU: MRC Integrative Epidemiology Unit Quinquennial renewal
Gaunt, L. F. (Principal Investigator) & Davey Smith, G. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research
IEU 2 Relton Programme - Epigenetic Epidemiology
Relton, C. L. (Principal Investigator)
1/04/18 → 31/03/23
Project: Research
(IEU) Epigenetics: Environment, Embodiment & Equality (E4)
Relton, C. L. (Principal Investigator)
1/01/16 → 31/12/19
Project: Research

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Sikdar, S., Joehanes, R., Joubert, B. R., Xu, C.-J., Vives-Usano, M., Rezwan, F. I., Felix, J. F., Ward, J. M., Guan, W., Richmond, R. C., Brody, J. A., Kupers, L. K., Baïz, N., Haberg, S. E., Smith, J. A., Reese, S. E., Aslibekyan, S., Hoyo, C., Dhingra, R., ... al., E. (2019). Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking. Epigenomics, 11(13), 1487-1500. Advance online publication. https://doi.org/10.2217/epi-2019-0066

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abstract = "Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.",

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Sikdar, S, Joehanes, R, Joubert, BR, Xu, C-J, Vives-Usano, M, Rezwan, FI, Felix, JF, Ward, JM, Guan, W, Richmond, RC, Brody, JA, Kupers, LK, Baïz, N, Haberg, SE, Smith, JA, Reese, SE, Aslibekyan, S, Hoyo, C, Dhingra, R, Markunas, CA, Relton, CL & al., E 2019, 'Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking', Epigenomics, vol. 11, no. 13, pp. 1487-1500. https://doi.org/10.2217/epi-2019-0066

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T1 - Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

AU - Sikdar, Sinjini

AU - Joehanes, Roby

AU - Joubert, Bonnie R

AU - Xu, Cheng-Jian

AU - Vives-Usano, Marta

AU - Rezwan, Faisal I

AU - Felix, Janine F

AU - Ward, James M

AU - Guan, Weihua

AU - Richmond, Rebecca C

AU - Brody, Jennifer A

AU - Kupers, Leanne K

AU - Baïz, Nour

AU - Haberg, Siri E

AU - Smith, Jennifer A

AU - Reese, Sarah E.

AU - Aslibekyan, Stella

AU - Hoyo, Cathrine

AU - Dhingra, Radhika

AU - Markunas, Christina A

AU - Relton, Caroline L

AU - al., et

PY - 2019/9/19

Y1 - 2019/9/19

N2 - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

AB - Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.

KW - cigarette smoking

KW - epigenetics

KW - infant

KW - maternal exposure

KW - methylation

U2 - 10.2217/epi-2019-0066

DO - 10.2217/epi-2019-0066

M3 - Article (Academic Journal)

C2 - 31536415

SN - 1750-1911

VL - 11

SP - 1487

EP - 1500

JO - Epigenomics

JF - Epigenomics

IS - 13

ER -

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Abstract

Research Groups and Themes

Keywords

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Projects

IEU: MRC Integrative Epidemiology Unit Quinquennial renewal

IEU 2 Relton Programme - Epigenetic Epidemiology

(IEU) Epigenetics: Environment, Embodiment & Equality (E4)

Cite this