Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

Sinjini Sikdar, Roby Joehanes, Bonnie R Joubert, Cheng-Jian Xu, Marta Vives-Usano, Faisal I Rezwan, Janine F Felix, James M Ward, Weihua Guan, Rebecca C Richmond, Jennifer A Brody, Leanne K Kupers, Nour Baïz, Siri E Haberg, Jennifer A Smith, Sarah E. Reese, Stella Aslibekyan, Cathrine Hoyo, Radhika Dhingra, Christina A MarkunasCaroline L Relton, et al.

Research output: Contribution to journalArticle (Academic Journal)peer-review

8 Citations (Scopus)
163 Downloads (Pure)

Abstract

Aim: Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and in adults from personal smoking. Whether a unique methylation signature exists for in utero exposure in newborns is unknown. Materials & methods: We separately meta-analyzed newborn blood DNA methylation (assessed using Illumina450k Beadchip), in relation to sustained maternal smoking during pregnancy (9 cohorts, 5648 newborns, 897 exposed) and adult blood methylation and personal smoking (16 cohorts, 15907 participants, 2433 current smokers). Results & conclusion: Comparing meta-analyses, we identified numerous signatures specific to newborns along with many shared between newborns and adults. Unique smoking-associated genes in newborns were enriched in xenobiotic metabolism pathways. Our findings may provide insights into specific health impacts of prenatal exposure on offspring.
Original languageEnglish
Pages (from-to)1487-1500
Number of pages14
JournalEpigenomics
Volume11
Issue number13
Early online date19 Sep 2019
DOIs
Publication statusE-pub ahead of print - 19 Sep 2019

Structured keywords

  • ICEP

Keywords

  • cigarette smoking
  • epigenetics
  • infant
  • maternal exposure
  • methylation

Fingerprint Dive into the research topics of 'Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking'. Together they form a unique fingerprint.

Cite this