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levels at age 12, among individuals who first reported psychotic experiences (PEs) at age 18 (n=64), were compared with age-matched controls (n=67). Six out of the 29 targeted complement proteins or protein subcomponents were significantly upregulated following correction for multiple comparisons (VTN↑, C1RL↑, C8B↑, C8A↑, CFH↑, C5↑).Using the same methods, we examined participants with Persistent Psychotic Experiences (PPE) at both
age 12 and age 18 (n=38) compared to age-matched controls who only experienced PEs at age 12 (n=38). Here, we observed that five of 29 targeted complement proteins were differentially expressed (C1RL↑, C2↑, C4BPB↑, C9↑, CFD↑). Finally, we undertook an unbiased plasma proteomic analysis of mice exposed to chronic social stress and observed dysregulation of 10 complement proteins including five that were altered in the same direction in individuals with either PE or PPE (C1R↑, CFH↑, C4BP↑, C5↑, C9↑). Our findings indicate that dysregulation of the complement protein pathway in blood is associated
with incidence and persistence of psychotic experiences and that these changes may reflect exposure to stress.