Complement-Related Regulates Autophagy in Neighboring Cells

Lin Lin, Frederico S.L.M. Rodrigues, Christina Kary, Alicia Contet, Mary Logan, Richard H.G. Baxter, Will Wood, Eric H. Baehrecke

Research output: Contribution to journalArticle (Academic Journal)peer-review

35 Citations (Scopus)

Abstract

Summary Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.
Original languageEnglish
Pages (from-to)158
Number of pages1
JournalCell
Volume170
Issue number1
Early online date29 Jun 2017
DOIs
Publication statusPublished - 29 Jun 2017

Keywords

  • autophagy
  • programmed cell death
  • complement
  • immune-receptor signaling

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