Composite outcomes: weighting component events according to severity assisted interpretation but reduced statistical power

Uchechukwu K A Sampson; Chris Metcalfe; Marc A Pfeffer; Scott D Solomon; Kelly H Zou

doi:10.1016/j.jclinepi.2010.01.019

Composite outcomes: weighting component events according to severity assisted interpretation but reduced statistical power

Uchechukwu K A Sampson, Chris Metcalfe, Marc A Pfeffer, Scott D Solomon, Kelly H Zou

Research output: Contribution to journal › Article (Academic Journal) › peer-review

16 Citations (Scopus)

Abstract

In trials of chronic disease therapy, each patient may experience several nonfatal illnesses and death. "Composite" outcome measures combine information from these different components of disease burden. Most common is the binary distinction between patients undergoing one or more events and those undergoing no events. We compare this approach with a composite score that preserves information on the number and severity of events.

Original language	English
Pages (from-to)	1156-8
Number of pages	3
Journal	Journal of Clinical Epidemiology
Volume	63
Issue number	10
DOIs	https://doi.org/10.1016/j.jclinepi.2010.01.019
Publication status	Published - 2010

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COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS
Blazeby, J. (Principal Investigator)
1/04/09 → 1/04/14
Project: Research

Cite this

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title = "Composite outcomes: weighting component events according to severity assisted interpretation but reduced statistical power",

abstract = "In trials of chronic disease therapy, each patient may experience several nonfatal illnesses and death. {"}Composite{"} outcome measures combine information from these different components of disease burden. Most common is the binary distinction between patients undergoing one or more events and those undergoing no events. We compare this approach with a composite score that preserves information on the number and severity of events.",

author = "Sampson, {Uchechukwu K A} and Chris Metcalfe and Pfeffer, {Marc A} and Solomon, {Scott D} and Zou, {Kelly H}",

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T2 - weighting component events according to severity assisted interpretation but reduced statistical power

AU - Sampson, Uchechukwu K A

AU - Metcalfe, Chris

AU - Pfeffer, Marc A

AU - Solomon, Scott D

AU - Zou, Kelly H

PY - 2010

Y1 - 2010

N2 - In trials of chronic disease therapy, each patient may experience several nonfatal illnesses and death. "Composite" outcome measures combine information from these different components of disease burden. Most common is the binary distinction between patients undergoing one or more events and those undergoing no events. We compare this approach with a composite score that preserves information on the number and severity of events.

AB - In trials of chronic disease therapy, each patient may experience several nonfatal illnesses and death. "Composite" outcome measures combine information from these different components of disease burden. Most common is the binary distinction between patients undergoing one or more events and those undergoing no events. We compare this approach with a composite score that preserves information on the number and severity of events.

U2 - 10.1016/j.jclinepi.2010.01.019

DO - 10.1016/j.jclinepi.2010.01.019

M3 - Article (Academic Journal)

C2 - 20558037

SN - 1878-5921

VL - 63

SP - 1156

EP - 1158

JO - Journal of Clinical Epidemiology

JF - Journal of Clinical Epidemiology

IS - 10

ER -

Composite outcomes: weighting component events according to severity assisted interpretation but reduced statistical power

Abstract

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COLLABORATION AND INNOVATION IN DIFFICULT OR RANDOMISED CONTROLLED TRIALS

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