Composite scaffolds for large bone defects

Evangelos Daskalakis; Fengyuan Liu; Glen Cooper; Andy Weightman; Bahattin Koc; Gordon Blunn; Paulo Bartolo

Composite scaffolds for large bone defects

Evangelos Daskalakis, Fengyuan Liu, Glen Cooper, Andy Weightman, Bahattin Koc, Gordon Blunn, Paulo Bartolo^*

^*Corresponding author for this work

Department of Mechanical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference Contribution (Conference Proceeding)

Abstract

This paper investigates the use of polymer-ceramic composite scaffolds for bone regeneration. Different ratios between Poly-εcaprolactone (PCL) and Hydroxyapatite (HA) were considered. Scaffolds were produced using two different lay-down patterns (0/90° and 0/45°), and pore sizes (350 μm, 500 μm and 700 μm). Compressive and cell proliferation tests are reported. Human adipose derived stem cells (hADSCs) were used for the biological characterization.

Original language	English
Title of host publication	Progress in Digital and Physical Manufacturing
Subtitle of host publication	Proceedings of ProDPM'19
Publisher	Springer
Pages	250-257
ISBN (Electronic)	978-3-030-29041-2
ISBN (Print)	978-3-030-29040-5, 978-3-030-29043-6
Publication status	Published - 2020

Publication series

Name	Lecture Notes in Mechanical Engineering
Publisher	Springer International Publishing
ISSN (Print)	2195-4356

Keywords

Hydroxyapatite
Bioprinting
Additive manufacturing
Tissue engineering

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title = "Composite scaffolds for large bone defects",

abstract = "This paper investigates the use of polymer-ceramic composite scaffolds for bone regeneration. Different ratios between Poly-εcaprolactone (PCL) and Hydroxyapatite (HA) were considered. Scaffolds were produced using two different lay-down patterns (0/90° and 0/45°), and pore sizes (350 μm, 500 μm and 700 μm). Compressive and cell proliferation tests are reported. Human adipose derived stem cells (hADSCs) were used for the biological characterization.",

keywords = "Hydroxyapatite, Bioprinting, Additive manufacturing, Tissue engineering",

author = "Evangelos Daskalakis and Fengyuan Liu and Glen Cooper and Andy Weightman and Bahattin Koc and Gordon Blunn and Paulo Bartolo",

year = "2020",

language = "English",

isbn = "978-3-030-29040-5",

series = "Lecture Notes in Mechanical Engineering ",

publisher = "Springer",

pages = "250--257",

booktitle = "Progress in Digital and Physical Manufacturing",

}

TY - GEN

T1 - Composite scaffolds for large bone defects

AU - Daskalakis, Evangelos

AU - Liu, Fengyuan

AU - Cooper, Glen

AU - Weightman, Andy

AU - Koc, Bahattin

AU - Blunn, Gordon

AU - Bartolo, Paulo

PY - 2020

Y1 - 2020

N2 - This paper investigates the use of polymer-ceramic composite scaffolds for bone regeneration. Different ratios between Poly-εcaprolactone (PCL) and Hydroxyapatite (HA) were considered. Scaffolds were produced using two different lay-down patterns (0/90° and 0/45°), and pore sizes (350 μm, 500 μm and 700 μm). Compressive and cell proliferation tests are reported. Human adipose derived stem cells (hADSCs) were used for the biological characterization.

AB - This paper investigates the use of polymer-ceramic composite scaffolds for bone regeneration. Different ratios between Poly-εcaprolactone (PCL) and Hydroxyapatite (HA) were considered. Scaffolds were produced using two different lay-down patterns (0/90° and 0/45°), and pore sizes (350 μm, 500 μm and 700 μm). Compressive and cell proliferation tests are reported. Human adipose derived stem cells (hADSCs) were used for the biological characterization.

KW - Hydroxyapatite

KW - Bioprinting

KW - Additive manufacturing

KW - Tissue engineering

M3 - Conference Contribution (Conference Proceeding)

SN - 978-3-030-29040-5

SN - 978-3-030-29043-6

T3 - Lecture Notes in Mechanical Engineering

SP - 250

EP - 257

BT - Progress in Digital and Physical Manufacturing

PB - Springer

ER -

Composite scaffolds for large bone defects

Abstract

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