TY - JOUR
T1 - Computational cardiology and risk stratification for sudden cardiac death
T2 - one of the grand challenges for cardiology in the 21st century
AU - Hill, Adam P
AU - Perry, Matthew D
AU - Abi-Gerges, Najah
AU - Couderc, Jean-Philippe
AU - Fermini, Bernard
AU - Hancox, Jules C
AU - Knollmann, Bjorn C
AU - Mirams, Gary R
AU - Skinner, Jon
AU - Zareba, Wojciech
AU - Vandenberg, Jamie I
N1 - This article is protected by copyright. All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Risk stratification in the context of sudden cardiac death has been acknowledged as one of the major challenges facing cardiology for the past four decades. In recent years, the advent of high performance computing has facilitated organ-level simulation of the heart, meaning we can now examine the causes, mechanisms and impact of cardiac dysfunction in silico. As a result, computational cardiology, largely driven by the Physiome project, now stands at the threshold of clinical utility in regards to risk stratification and treatment of patients at risk of sudden cardiac death. In this white paper, we outline a roadmap of what needs to be done to make this translational step, using the relatively well developed case of acquired or drug-induced long QT syndrome as an exemplar case.
AB - Risk stratification in the context of sudden cardiac death has been acknowledged as one of the major challenges facing cardiology for the past four decades. In recent years, the advent of high performance computing has facilitated organ-level simulation of the heart, meaning we can now examine the causes, mechanisms and impact of cardiac dysfunction in silico. As a result, computational cardiology, largely driven by the Physiome project, now stands at the threshold of clinical utility in regards to risk stratification and treatment of patients at risk of sudden cardiac death. In this white paper, we outline a roadmap of what needs to be done to make this translational step, using the relatively well developed case of acquired or drug-induced long QT syndrome as an exemplar case.
U2 - 10.1113/JP272015
DO - 10.1113/JP272015
M3 - Article (Academic Journal)
C2 - 27060987
SN - 0022-3751
VL - 594
SP - 6893
EP - 6908
JO - Journal of Physiology
JF - Journal of Physiology
IS - 23
ER -