Projects per year
requires both detailed and quantitative mathematical and experimental models of the processes to (re)design, and software and tools for genetic engineering and DNA assembly. Ultimately, the increased precision in the design phase will have a dramatic impact on the production of designer cells and organisms with bespoke functions and increased modularity. Computer-aided design strategies require quantitative representations of cells, able to capture multiscale processes and link genotypes to phenotypes. Here, we present a perspective on how whole-cell, multiscale models could transform design-build-test-learn cycles in synthetic biology. We show how these models could significantly aid in the design and learn phases while reducing experimental testing by presenting case studies spanning from genome minimization to cell-free systems, and we discuss several challenges for the realization of our vision. The possibility to describe and build in silico whole-cells offers an opportunity to develop increasingly automatized, precise and accessible computer-aided design tools and strategies throughout novel interdisciplinary collaborations.
- Genome Design
- Bristol BioDesign Institute
- Engineering Mathematics Research Group
- Whole-Cell Models
- Synthetic Biology
- Systems Biology
FingerprintDive into the research topics of 'Computer-aided whole-cell design: taking a holistic approach by integrating synthetic with systems biology'. Together they form a unique fingerprint.
- 1 Active
1/10/19 → 30/09/24
Rees-Garbutt, J. P., 26 Nov 2020
Student thesis: Doctoral Thesis › Doctor of Philosophy (PhD)File