Concise Review: Diabetes, the Bone Marrow Niche, and Impaired Vascular Regeneration

Gian Paolo Fadini*, Francesca Ferraro, Federico Quaini, Takayuki Asahara, Paolo Madeddu

*Corresponding author for this work

Research output: Contribution to journalReview article (Academic Journal)peer-review

61 Citations (Scopus)

Abstract

Diabetes mellitus is a global health problem that results in multiorgan complications leading to high morbidity and mortality. Until recently, the effects of diabetes and hyperglycemia on the bone marrow microenvironment-a site where multiple organ systems converge and communicate-have been underappreciated. However, several new studies in mice, rats, and humans reveal that diabetes leads to multiple bone marrow microenvironmental defects, such as small vessel disease (microangiopathy), nerve terminal pauperization (neuropathy), and impaired stem cell mobilization (mobilopathy). The discovery that diabetes involves bone marrow-derived progenitors implicated in maintaining cardiovascular homeostasis has been proposed as a bridging mechanism between micro-and macroangiopathy in distant organs. Herein, we review the physiological and molecular bone marrow abnormalities associated with diabetes and discuss how bone marrow dysfunction represents a potential root for the development of the multiorgan failure characteristic of advanced diabetes. The notion of diabetes as a bone marrow and stem cell disease opens new avenues for therapeutic interventions ultimately aimed at improving the outcome of diabetic patients.

Original languageEnglish
Pages (from-to)949-957
Number of pages9
JournalStem Cells Translational Medicine
Volume3
Issue number8
DOIs
Publication statusPublished - Aug 2014

Bibliographical note

©AlphaMed Press.

Keywords

  • Complications
  • Stem cells
  • Regeneration
  • HEMATOPOIETIC STEM-CELLS
  • ENDOTHELIAL PROGENITOR CELLS
  • IN-VIVO
  • PHENOTYPIC HETEROGENEITY
  • SIGNALING PATHWAY
  • MOBILIZATION
  • ATHEROSCLEROSIS
  • VASCULOGENESIS
  • COMPLICATIONS
  • MELLITUS

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