Concise review: MicroRNAs as modulators of stem cells and angiogenesis

Nicole M Kane, Adrian J Thrasher, Gianni D Angelini, Costanza Emanueli

Research output: Contribution to journalArticle (Academic Journal)peer-review

61 Citations (Scopus)

Abstract

MicroRNAs (miRs) are highly conserved, short noncoding RNA molecules that negatively regulate messenger RNA (mRNA) stability and/or translational efficiency. Since a given miR can control the expression of many mRNAs, their importance in governing gene expression in specific cell types including vascular cells and their progenitor cells has become increasingly clear. Understanding how the expression of miRs themselves is regulated and how miRs exert their influence on post-transcriptional gene control provides novel opportunities to dissect gene regulatory networks in clinically relevant cell types. A multitude of miRs have been identified with key roles in vascular development, homeostasis, function, disease, and regeneration. In this review, we will describe the impact of miRs on angiogenesis and their capacity to modulate the behavior of stem and progenitor cells which may be utilitarian for promoting vascular growth in ischemic tissue. Moreover, we summarize these strategies available for modulating miR expression and function and future therapeutic applications.

Original languageEnglish
Pages (from-to)1059-66
Number of pages8
JournalStem Cells
Volume32
Issue number5
DOIs
Publication statusPublished - May 2014

Structured keywords

  • Centre for Surgical Research

Keywords

  • Animals
  • Cell Differentiation
  • Endothelial Cells
  • Gene Expression Regulation
  • Humans
  • MicroRNAs
  • Models, Genetic
  • Neovascularization, Pathologic
  • Neovascularization, Physiologic
  • Stem Cells

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