Concise synthesis of a pentasaccharide repeating unit corresponding to the O-antigen of Escherichia coli O102

Abhijit Sau, Debashis Dhara, Anup Kumar Misra*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

2 Citations (Scopus)

Abstract

An efficient synthetic strategy has been developed for the synthesis of a pentasaccharide repeating unit of the O-antigen of Escherichia coli O102 strain. The target pentasaccharide 1 has been synthesized using a [2+3] block glycosylation strategy. All glycosylation steps are highly stereoselective and high yielding. Concept of armed-disarmed and orthogonal glycosylation strategies has been applied during the synthesis. The target compound has been synthesized using the minimum number of steps.

Original languageEnglish
Pages (from-to)942-946
Number of pages5
JournalTetrahedron: Asymmetry
Volume24
Issue number15-16
DOIs
Publication statusPublished - 31 Aug 2013

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