Hepatic disease is a known risk factor for the development of bone infection in human beings. Three dogs with portosystemic shunting and concurrent physitis are presented here and an association is postulated between both disease processes. Portosystemic shunting may be a risk factor for the development of physitis in dogs. Skeletal structures should not be overlooked when reviewing diagnostic imaging studies of dogs with portosystemic shunts. Skeletal infections should be considered as a differential diagnosis in dogs with liver disease and concurrent skeletal abnormalities.