Conditions for the generation of beta oscillations in the subthalamic nucleus - globus pallidus network

AJ Nevado Holgado, JR Terry, R Bogacz

Research output: Contribution to journalArticle (Academic Journal)peer-review

140 Citations (Scopus)

Abstract

The advance of Parkinson's disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13-30Hz). Whilst the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus pars externa (GPe). To investigate this hypothesis we develop a computational model of the STN-GPe network based upon anatomical and electrophysiological studies. Significantly, our study shows that for certain parameter regimes, the model intrinsically oscillates in the beta range. Through an analytical study of the model we identify a simple set of necessary conditions on model parameters, which guarantees the existence of beta oscillations. These conditions for generation of oscillations are described by a set of simple inequalities and can be summarised as follows: (i) The excitatory connections from STN to GPe and the inhibitory connections from GPe to STN need to be sufficiently strong. (ii) The time required by neurons to react to their inputs needs to be short relative to synaptic transmission delays. (iii) The excitatory input from the cortex to STN needs to be high relative to the inhibition from striatum to GPe. We confirmed the validity of these conditions via numerical simulation. These conditions describe changes in parameters that are consistent with those expected as a result of the development of Parkinon's disease, and predict manipulations that could inhibit the pathological oscillations.
Translated title of the contributionConditions for the generation of beta oscillations in the subthalamic nucleus - globus pallidus network
Original languageEnglish
Article number12340-12352
Pages (from-to)12340 - 12352
JournalJournal of Neuroscience
Volume30
DOIs
Publication statusPublished - 2010

Bibliographical note

Other identifier: 2001230

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