Confinement-Induced Transition between Wavelike Collective Cell Migration Modes

Vanni Petrolli, Magali Le Goff, Monika Tadrous, Kirsten Martens, Cédric Allier, Ondrej Mandula, Lionel Hervé, Silke Henkes, Rastko Sknepnek, Thomas Boudou, Giovanni Cappello, Martial Balland

Research output: Contribution to journalArticle (Academic Journal)

8 Citations (Scopus)
218 Downloads (Pure)

Abstract

The structural and functional organization of biological tissues relies on the intricate interplay between chemical and mechanical signaling. Whereas the role of constant and transient mechanical perturbations is generally accepted, several studies recently highlighted the existence of long-range mechanical excitations (i.e., waves) at the supracellular level. Here, we confine epithelial cell monolayers to quasi-one-dimensional geometries, to force the establishment of tissue-level waves of well-defined wavelength and period. Numerical simulations based on a self-propelled Voronoi model reproduce the observed waves and exhibit a phase transition between a global and a multinodal wave, controlled by the confinement size. We confirm experimentally the existence of such a phase transition, and show that wavelength and period are independent of the confinement length. Together, these results demonstrate the intrinsic origin of tissue oscillations, which could provide cells with a mechanism to accurately measure distances at the supracellular level.

Original languageEnglish
Article number168101
Number of pages5
JournalPhysical Review Letters
Volume122
Issue number16
DOIs
Publication statusPublished - 24 Apr 2019

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