Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

Julien Maury, Bryden A F Le Bailly, James Raftery, Jonathan Clayden*

*Corresponding author for this work

Research output: Contribution to journalArticle (Academic Journal)peer-review

14 Citations (Scopus)

Abstract

Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.

Original languageEnglish
Pages (from-to)11802-11805
Number of pages4
JournalChemical Communications
Volume51
Issue number59
Early online date5 Jun 2015
DOIs
Publication statusPublished - 28 Jul 2015

Bibliographical note

Date of Acceptance: 05/06/2015 (cited by 0)

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