Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

Julien Maury; Bryden A F Le Bailly; James Raftery; Jonathan Clayden

doi:10.1039/c5cc02995c

Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

Julien Maury, Bryden A F Le Bailly, James Raftery, Jonathan Clayden^*

^*Corresponding author for this work

School of Chemistry

Research output: Contribution to journal › Article (Academic Journal) › peer-review

16 Citations (Scopus)

Abstract

Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.

Original language	English
Pages (from-to)	11802-11805
Number of pages	4
Journal	Chemical Communications
Volume	51
Issue number	59
Early online date	5 Jun 2015
DOIs	https://doi.org/10.1039/c5cc02995c
Publication status	Published - 28 Jul 2015

Bibliographical note

Date of Acceptance: 05/06/2015 (cited by 0)

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Organic & Biological

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title = "Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras",

abstract = "Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.",

author = "Julien Maury and \{Le Bailly\}, \{Bryden A F\} and James Raftery and Jonathan Clayden",

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T1 - Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

AU - Maury, Julien

AU - Le Bailly, Bryden A F

AU - Raftery, James

AU - Clayden, Jonathan

N1 - Date of Acceptance: 05/06/2015 (cited by 0)

PY - 2015/7/28

Y1 - 2015/7/28

N2 - Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.

AB - Linking together an oligourea and an oligoamide foldamer gives rise to a conformationally well-defined structure, despite the different hydrogen-bonding patterns in the two domains, provided the oligomers are ligated amide C terminus to urea N terminus. A powerful screw-sense preference induced at the N terminus of the resulting chimeric structure provides evidence for cooperative conformational interactions within the 'block co-foldamer'.

UR - https://www.scopus.com/pages/publications/84936970816

U2 - 10.1039/c5cc02995c

DO - 10.1039/c5cc02995c

M3 - Article (Academic Journal)

C2 - 26107614

AN - SCOPUS:84936970816

SN - 1359-7345

VL - 51

SP - 11802

EP - 11805

JO - Chemical Communications

JF - Chemical Communications

IS - 59

ER -

Conformational cooperativity between helical domains of differing geometry in oligoamide-oligourea foldamer chimeras

Abstract

Bibliographical note

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